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Article type: Research Article
Authors: Ohara, Kensuke | Kuriyama, Chiaki | Hada, Takuya | Suzuki, Shin | Nakayama, Yasuhide | Abo, Masahiro; *
Affiliations: Department of Rehabilitation Medicine, The Jikei University School of Medicine, Tokyo, Japan
Correspondence: [*] Address for correspondence: Dr Masahiro Abo, Department of Rehabilitation Medicine, The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-Ku, Tokyo 105-8461, Japan. Tel.: +81 3 3433 1111; Fax: +81 3 3431 1206; E-mail: [email protected].
Abstract: BACKGROUND:A lot of research on the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with aphasia in the chronic stage deals with low-frequency stimulation, and reports on high-frequency stimulation (HF-rTMS) are scarce. OBJECTIVE:The purpose of this study was to evaluate retrospectively the effectiveness of high-frequency rTMS in combination with intensive speech-language-hearing therapy (ST) following the identification of the stimulation site using functional magnetic resonance imaging (fMRI) before, after the procedure and at 3 months in patients with aphasia in the chronic stage. METHODS:20 patients with aphasia in the chronic stage who met the eligibility criteria for rTMS therapy and who underwent HF-rTMS for the first time were included in the present study. All patients received fMRI before hospitalization, and the stimulation site was decided accordingly. RESULTS:There was a significant improvement in all patients, rTMS to the left hemisphere, fluent and non-fluent groups by the evaluation of pre- and post- treatment by hospitalization. All groups had a significant improvement in total Standard Language Test of Aphasia score at 3 months when compared with the time of hospitalization. CONCLUSIONS:The current study indicates that HF-rTMS in combination with intensive ST is an effective therapeutic approach for patients with aphasia in the chronic stage.
Keywords: rTMS, aphasia, fMRI, speech-language-hearing therapy, high-frequency, stroke
DOI: 10.3233/NRE-210139
Journal: NeuroRehabilitation, vol. 49, no. 3, pp. 459-467, 2021
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