Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Luan, Shuoa; 1 | Wu, Shao-Linga; 1 | Xiao, Ling-Juna | Yang, Hai-Yunb | Liao, Mei-Xina | Wang, Shao-Linga | Fan, Sheng-Nuoa | Ma, Chaoa; *
Affiliations: [a] Department of Rehabilitation, Sun Yat-sen Memorial Hospital, Guangzhou, People’s Republic of China | [b] Department of Ultrasonic, Sun Yat-sen Memorial Hospital, Guangzhou, People’s Republic of China
Correspondence: [*] Address for correspondence: Chao Ma, Department of Rehabilitation Medicine, Sun Yat-sen Memorial Hospital, No. 107 Yanjiang West Road, Guangzhou, China. Tel.: +02081332513; E-mail: [email protected].
Note: [1] Shuo Luan and Shao-ling Wu contributed equally to this work.
Abstract: BACKGROUND:Cricopharyngeal muscle dysfunction (CPD) management has been challenging in clinical practice. OBJECTIVE:To compare the efficacy and safety of ultrasound-guided botulinum toxin injection and balloon catheter dilatation in treating CPD. METHODS:Forty patients with CPD were randomly divided into two groups, namely the botulinum toxin injection group (BTX group) and balloon dilatation group (BD group). Patients in the BTX group received a single ultrasound-guided injection of 50 units of botulinum toxin type A, while the BD group received dilatation therapy five times per week, consecutively for two weeks. Relative opening percentage of the upper esophageal sphincter (UES), the penetration-aspiration scale (PAS), and the Dysphagia Outcome Severity Scale (DOSS) were evaluated by a videofluoroscopic swallowing study (VFSS) at baseline, 1-month, and 3-months posttreatment. The Functional Oral Intake Scale (FOIS) and Standardized Swallowing Assessment (SSA) were also used to evaluate participants’ swallowing function at baseline and the 1-week, 2-week, 1-month, and 3-month follow-ups. RESULTS:A generalized estimating equation (GEE) model revealed the significant main effect for time in UES, PAS, DOSS, FOIS, and SSA compared to baseline (P <0.05), while no group-by-time interactions (except for the PAS assessment) or main effect for treatment was detected among the above multiple variances. No systematic complications or severe adverse effects were noted. CONCLUSION:Both ultrasound-guided botulinum toxin type A injections and balloon dilatation therapy have been proven as safe and effective treatments for CPD patients. Future clinical trials with longer follow-up periods and more participants are warranted.
Keywords: Neurogenic cricopharyngeal muscle dysfunction, ultrasound-guided botulinum toxin injection, balloon catheter dilatation therapy, dysphagia
DOI: 10.3233/NRE-210113
Journal: NeuroRehabilitation, vol. 49, no. 4, pp. 629-639, 2021
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]