Change in mobility function and its causes in adults with cerebral palsy by Gross Motor Function Classification System level: A cross-sectional questionnaire study

Article type: Research Article

Authors: Himuro, Nobuaki^{a; *} | Mishima, Reiko^b | Seshimo, Takashi^c | Morishima, Toshibumi^d | Kosaki, Keisuke^e | Ibe, Shigeharu^f | Asagai, Yoshimi^g | Minematsu, Koji^h | Kurita, Kazuhiroⁱ | Okayasu, Tsutomu^j | Shimura, Tsukasa^k | Hoshino, Kotaro^l | Suzuki, Toshiro^m | Yanagizono, Taiichiroⁿ

Affiliations: [a] Department of Public Health, School of Medicine, Sapporo Medical University, Sapporo, Hokkaido, Japan | [b] Asahikawa Center for Disabled Children, Asahikawa, Hokkaido, Japan | [c] Rehabilitation Edelweiss Hospital, Itabashi-ku, Tokyo, Japan | [d] Hamanasu Rehabilitation Center for Children with Disabilities, Hachinohe, Aomori, Japan | [e] Department of Orthopedic Surgery, National Rehabilitation Center for Children with Disabilities, Itabashi-ku, Tokyo, Japan | [f] Aiseikai Memorial Ibaraki Welfare Medical Center, Mito, Ibaraki, Japan | [g] Shinano Handicapped Children’s Hospital, Shimosuwa, Nagano, Japan | [h] Toyama Prefectural Rehabilitation Hospital and Support Center for Children with Disabilities, Toyama, Toyama, Japan | [i] Department of Orthopedics, Aichi Aoitori Habilitation Center for Challenged, Nagoya, Aichi, Japan | [j] Department of Orthopaedic Surgery, Aitoku Medical and Welfare Center, Wakayama, Wakayama, Japan | [k] Hiroshima Prefectural Rehabilitation Center Wakakusa-en, Higashihiroshima, Hiroshima, Japan | [l] Department of Orthopedic Surgery, West-Shimane Rehabilitation Center for Children with Disabled Children, Gotsu, Shimane, Japan | [m] Medical Corporation Ozaki Hospital, Tottori, Tottori, Japan | [n] Division of Orthopedic Surgery, Miyazaki Prefecture Center for Disabled Children, Miyazaki, Miyazaki, Japan

Correspondence: [*] Address for correspondence: Nobuaki Himuro, Assistant Professor, Department of Public Health, School of Medicine, Sapporo Medical University, South 1 West 17, Chuo-ku, Sapporo, Hokkaido 060-8556, Japan. Tel.: +81 11 611 2111/Ext. 2766; E-mail: [email protected].

Abstract: BACKGROUND:The prognosis for mobility function by Gross Motor Function Classification System (GMFCS) level is vital as a guide to rehabilitation for people with cerebral palsy. OBJECTIVE:This study sought to investigate change in mobility function and its causes in adults with cerebral palsy by GMFCS level. METHODS:We conducted a cross-sectional questionnaire study. RESULTS:A total of 386 participants (26 y 8 m, SD 5 y 10 m) with cerebral palsy were analyzed. Participant numbers by GMFCS level were: I (53), II (139), III (74) and IV (120). The median age of participants with peak mobility function in GMFCS level III was younger than that in the other levels. 48% had experienced a decline in mobility. A Kaplan-Meier plot showed the risk of mobility decline increased in GMFCS level III; the hazard ratio was 1.97 (95% CI, 1.20–3.23) compared with level I. The frequently reported causes of mobility decline were changes in environment, and illness and injury in GMFCS level III, stiffness and deformity in level IV, and reduced physical activity in level II and III. CONCLUSIONS:Peak mobility function and mobility decline occurred at a younger age in GMFCS level III, with the cause of mobility decline differing by GMFCS level.

Keywords: Cerebral palsy, mobility, gross motor function

DOI: 10.3233/NRE-172340

Journal: NeuroRehabilitation, vol. 42, no. 4, pp. 383-390, 2018