Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Rudroff, T.a; * | Kindred, J.H.a | Koo, P.J.b | Karki, R.b | Hebert, J.R.c
Affiliations: [a] Department of Health and Exercise Science, Colorado State University, Fort Collins, CO, USA | [b] Department of Radiology, University of Colorado School of Medicine, Aurora, CO, USA | [c] Department of Physical Medicine & Rehabilitation – Physical Therapy Program, University of Colorado School of Medicine, Aurora, CO, USA
Correspondence: [*] Address for correspondence: Thorsten Rudroff, Department of Health and Exercise Science, Colorado State University, 220 Moby B Complex, Fort Collins, CO 80523-1582, USA. Tel.: +970 491 8655; Fax: +970 491 0455; E-mail: [email protected]
Abstract: Background:In patients with Multiple Sclerosis (MS), comparative leg muscle strength asymmetries are common and typically accompanied by walking difficulties. Underlying mechanisms for these asymmetries are not completely known, but altered muscle energetics may play a role. Objective:To investigate glucose uptake asymmetries in leg muscles of patients with mild MS during walking. Methods:Eight MS and 8 healthy control (CON) participants performed a 15-min treadmill walking test at self-selected speed. They were injected with a glucose tracer (18F-FDG) two minutes into the test and immediately upon completion, underwent Positron Emission Tomography/Computed Tomography (PET/CT) imaging. Results:MS group walked at a lower speed than the healthy control group (P < 0.01), however it was found that: 1) ([18F]-FDG) uptake in knee and hip flexors was higher compared to the CON group (P = 0.02); 2) the MS group exhibited asymmetrical strength of the knee flexors (P = 0.03); 3) [18F]-FDG uptake was significantly lower in the weaker knee flexors of patients with MS (P < 0.01). Conclusions:[18F]-FDG uptake and strength asymmetries in the legs of patients with MS indicate greater metabolic costs during activity, which may play a major role in premature muscle fatigability and subsequent impaired walking capacity.
Keywords: Positron emission tomography, glucose uptake, strength asymmetries, multiple sclerosis
DOI: 10.3233/NRE-141179
Journal: NeuroRehabilitation, vol. 35, no. 4, pp. 813-823, 2014
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]