EMG-force relation in the first dorsal interosseous muscle of patients with amyotrophic lateral sclerosis

Article type: Research Article

Authors: Jahanmiri-Nezhad, Faezeh^{a; b} | Hu, Xiaogang^a | Suresh, Nina L.^a | Rymer, William Z.^{a; c} | Zhou, Ping^{d; e; *}

Affiliations: [a] Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL, USA | [b] Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA | [c] Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, USA | [d] Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston and TIRR Memorial Hermann Research Center, Houston, TX, USA | [e] Biomedical Engineering Program, University of Science and Technology of China, Hefei, Anhui, China

Correspondence: [*] Address for correspondence: Ping Zhou, Ph.D., 1333 Moursund Street, Houston, TX 77030, USA. Tel.: +1 312 238 1365; Fax: +1 312 238 2208; E-mail: [email protected]

Abstract: Background and purpose:The relationship between surface electromyography (EMG) and muscle force is essential to assess muscle function and its deficits. However, few studies have explored the EMG-force relation in patients with amyotrophic lateral sclerosis (ALS). The purpose of this study was to examine the EMG-force relation in ALS subjects and its alteration in comparison with healthy control subjects. Methods:Surface EMG and force signals were recorded while 10 ALS and 10 age-matched healthy control subjects produced isometric voluntary contractions in the first dorsal interosseous (FDI) muscle over the full range of activation. A linear fit of the EMG-force relation was evaluated through the normalized root mean square error (RMSE) between the experimental and predicted EMG amplitudes. The EMG-force relation was compared between the ALS and the healthy control subjects. Results:With a linear fit, the normalized RMSE between the experimental and predicted EMG amplitudes was 9.6 ± 3.6% for the healthy control subjects and 12.3 ± 8.0% for the ALS subjects. The slope of the linear fit was 2.9 ± 2.2 μVN−1 for the ALS subjects and was significantly shallower (p < 0.05) than the control subjects (5.1 ± 1.8 μVN−1). However, after excluding the four ALS subjects who had very weak maximum force, the slope for the remaining ALS subjects was 3.5 ± 2.2 μVN−1 and was not significantly different from the control subjects (p > 0.05). Conclusions:A linear fit can be used to well describe the EMG-force relation for the FDI muscle of both ALS and healthy control subjects. A variety of processes may work together in ALS that can adversely affect the EMG-force relation.

Keywords: ALS, EMG-force relation, FDI, isometric contraction

DOI: 10.3233/NRE-141125

Journal: NeuroRehabilitation, vol. 35, no. 2, pp. 307-314, 2014