A simple model of signal transduction networks in molecular biology consists of CNF formulas with two and three literals per clause. A necessary condition for correctness of the network model is satisfiability of the formulas. Deciding satisfiability turns out to be -complete. However, for a subclass that still is of practical interest, a linear satisfiability algorithm and related characterization of unsatisfiability can be established. The subclass is a special case of so-called closed sums of CNF formulas.