Affiliations: [a] Department of Otolaryngology, School of Medicine, Gyeongsang National University, Jinju, South Korea | [b] Clinical Research Institute, School of Medicine, Gyeongsang National University, Jinju, South Korea | [c] Department of Otolaryngology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Correspondence:
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Corresponding author: Seong-Ki Ahn, M.D., Ph.D., Department of Otolaryngology, School of Medicine, Gyeongsang National University, Jinju, 660-702, South Korea. Tel.: +82 55 750 8176; Fax: +82 55 759 0613; E-mail: [email protected]
Note: [1] These two authors contributed equally to this study
Abstract: The association between migraine and balance disorder morbidities has been a topic of interest for many years, and serotonin (5-HT) receptor is known to be closely related with migraine and also to be associated with vestibular symptoms. However, the mechanism underlying the pathogenesis of migrainous vertigo and its association with 5-HT has not been elucidated. Of the many 5-HT receptors, 5-HT7 receptor has recently attracted attention in the context of migraine treatment. The purpose of this study was to investigate the localization and expression of 5-HT7 receptor in the rat vestibular nuclei by immunohistochemical staining and reverse transcriptase-polymerase chain reaction (RT-PCR). The present study might provide additional insight into the role of 5-HT7 receptor in the pathogenesis of migraine-related vestibular symptoms.
