Genotyping a new, national household panel study: White paper prepared for NSF-sponsored Conference, May 2014
Issue title: Assessing the need for a new nationally representative household
panel survey in the United States
Subtitle:
Guest editors: Robert Moffitt, Robert F. Schoeni, Charles Brown, P. Lindsay Chase-Lansdale, Mick P. Couper, Ana V. Diez-Roux, Erik Hurst and Judith A. Seltzer
Affiliations: Departments of Sociology, Medicine and Public Policy, New York University, New York, USA. E-mail: [email protected]
Abstract: In this paper, I demonstrate that existing social surveys that include
genotypic markers are all limited on at least one of the following
dimensions: national representativeness (versus targeted sample), genotyping
platform (candidate genes v. genome-wide measures), data structure (i.e.
individuals v. pedigrees), or measured phenotypes (lack of rich longitudinal
socioeconomic and developmental measures). Given this, I argue that the U.S.
either needs a novel, nationally representative household panel study that
includes genome-wide marker data or to genotype all respondents of the
existing Panel Study of Income Dynamics. I conclude by showing that such a
study would be adequately powered to deploy Genetic Risk Score analysis and
that, in turn, such scores could be deployed to model gene-environment
interaction effects.
Keywords: Genotype, G × E, national household panel, behavior genetics, Socio-genomics
