Affiliations: [a] Department of Neurology, Bozok University Medical School, Yozgat, Turkey | [b] Department of Physical Treatment and Rehabilitation, Bozok University Medical School, Yozgat, Turkey | [c] Department of Physical Medicine and Rehabilitation, Yozgat State Hospital, Yozgat, Turkey | [d] Department of Neurosurgery, Bozok University Medical School, Yozgat, Turkey | [e] Department of Biochemistry, Bozok University Medical School, Yozgat, Turkey
Correspondence:
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Corresponding author: Nermin Tanik, Department of Neurology, Bozok University Medical School, 66200 Yozgat, Turkey. Tel.: +90 505 950 48 44; Fax: +90 354 217 71 50; E-mail: [email protected]
Abstract: OBJECTIVE: Vitamin D deficiencies are associated with a variety of chronic diseases. The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS). METHODS: This study included 90 patients with mild to moderate CTS and assessed their routine serum 25-hydroxyvitamin D levels. Additionally, the pain level of each subject was evaluated using the Visual Analogue Scale and the Douleur Neuropathique 4 Questionnaire (DN4). RESULTS: The severity levels of CTS were at a 75% mild level in the vitamin D deficiency group and a 47.1% mild level in the vitamin D normal group, with a significant difference between groups (p = 0.008). Correlation analyses revealed positive correlations between body mass index and DN4 scores (r = 0.499,
p = 0.025) and between vitamin D levels and CTS severity (r = 0.364, p = 0.004) in the vitamin D deficiency group. CONCLUSIONS: The present findings demonstrated that CTS may be triggered by vitamin D deficiency, and that the severity of CTS was correlated with vitamin D levels in the deficiency group. Additionally, there was a correlation between weight gain and neuropathic pain intensity in CTS patients with vitamin D deficiency. The present findings indicate that vitamin D levels should be assessed in CTS patients.
