Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Chatelin, Simon | Oudry, Jennifer; | Périchon, Nicolas | Sandrin, Laurent | Allemann, Pierre | Soler, Luc | Willinger, Rémy;
Affiliations: University of Strasbourg, IMFS-CNRS, Strasbourg, France | Department of Research and Development, Echosens, Paris, France | Institut de Recherche contre les Cancers de l'Appareil Digestif, Strasbourg, France
Note: [] Address for correspondence: Rémy Willinger, University of Strasbourg, IMFS-CNRS, 2 rue Boussingault, 67000 Strasbourg, France. Tel.: +33 3 68 85 29 23; Fax: +33 3 68 85 29 36; E-mail: [email protected].
Abstract: Understanding the mechanical properties of human liver is one of the most critical aspects of its numerical modeling for medical applications or impact biomechanics. Generally, model constitutive laws come from in vitro data. However, the elastic properties of liver may change significantly after death and with time. Furthermore, in vitro liver elastic properties reported in the literature have often not been compared quantitatively with in vivo liver mechanical properties on the same organ. In this study, both steps are investigated on porcine liver. The elastic property of the porcine liver, given by the shear modulus G, was measured by both Transient Elastography (TE) and Dynamic Mechanical Analysis (DMA). Shear modulus measurements were realized on in vivo and in vitro liver to compare the TE and DMA methods and to study the influence of testing conditions on the liver viscoelastic properties. In vitro results show that elastic properties obtained by TE and DMA are in agreement. Liver tissue in the frequency range from 0.1 to 4 Hz can be modeled by a two-mode relaxation model. Furthermore, results show that the liver is homogeneous, isotropic and more elastic than viscous. Finally, it is shown in this study that viscoelastic properties obtained by TE and DMA change significantly with post mortem time and with the boundary conditions.
Keywords: Soft tissues, liver, viscoelasticity, transient elastography, dynamic mechanical analysis
DOI: 10.3233/BIR-2011-0584
Journal: Biorheology, vol. 48, no. 2, pp. 75-88, 2011
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]