Affiliations: University of Medicine and Pharmacy, Faculty of Medical Bioengineering, Iasi, Romania | School of Biological Sciences, University of Aberdeen, Aberdeen, UK | The Cleveland Clinic Foundation, 9500 Euclid Ave T28, Cleveland, OH, USA
Note: [] Address for correspondence: Dr. O. Rotariu, School of Biological Sciences, University of Aberdeen, Cruickshank Building, St. Machar Drive, Aberdeen, AB24 3UU, UK. Tel.: +44 01224 272256; Fax: +44 01224 272703; E‐mail: [email protected].
Abstract: The in vivo targeting of tumors with magnetic microspheres is currently realized through the application of external non‐uniform magnetic fields generated by rare‐earth permanent magnets or electromagnets. Our theoretical work suggests a feasible procedure for local delivery of magnetic nano‐ and microparticles to a target area. In particular, thin magnetizable wires placed throughout or close to the target area and magnetized by a perpendicular external uniform background magnetic field are used to concentrate magnetic microspheres injected into the target organ's natural blood supply. The capture of the magnetic particles and the building of deposits thereof in the blood vessels of the target area were modeled under circumstances similar to the in vivo situation. This technique could be applied to magnetically targeted cancer therapy or magnetic embolization therapy with magnetic particles that contain anticancer agents, such as chemotherapeutic drugs or therapeutic radioisotopes.
Keywords: Magnetic targeting, ferromagnetic wires, magnetic capture, magnetic drug targeting, local radiotherapy, emboliza‐ tion, magnetic microspheres, magnetic nanospheres
Journal: Biorheology, vol. 41, no. 5, pp. 599-612, 2004
