Fiber-Optic Laser-Doppler Anemometer Microscope Applied to the Cerebral Microcmculation in Rats

Article type: Short Communication

Authors: Seki, J.^{a; *} | Sasaki, Y.^b | Oyama, T.^b | Yamamoto, J.^b

Affiliations: [a] Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan | [b] Laboratory of Physiology, Faculty of Nutrition, Kobe-Gakuin University, Kobe, Japan

Correspondence: [*] Address for correspondence: Dr. Junji Seki, Department of Biomedical Engineering, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan Fax: +81-6-872-7485

Abstract: We have applied our developed fiber-optic laser-Doppler anemometer microscope (FLDAM) for the study of the cerebral microcirculation in the rat. The red cell velocity in single pial microvessels was successfully measured through a closed cranial window for the vessel diameter range from 7.8 to 230 µm. The temporal resolution of the FLDAM was sufficiently high to detect the pulsation in the arterioles. Arterio-venous distributions of the temporal mean red cell velocity and wall shear rate are also descri bed.

Keywords: Red cell velocity, laser-Doppler anemometer, wall shear rate, velocity-diameter relation, closed cranial window

DOI: 10.3233/BIR-1996-33604

Journal: Biorheology, vol. 33, no. 6, pp. 463-470, 1996