Orbitometer flow and thrombus formation

Article type: Research Article

Authors: Hartert, H.

Affiliations: Richard-Wagner-Str. 1, 6750 Kaiserslautern, FRG

Note: [] Accepted by: Editor-in-Chief S. Witte

Abstract: Orbitometry (Hartert) is a rheological ex-vivo method to follow up physical assembly of a coagulum in layers during natural intensity of flow by orbital movement. Fibrin elasticity in the Orbitometers mode of Resonance Thrombography is differentiated from platelet activity as well as e.g. from the effects of disseminated coagulation - minimal in liver disease and maximal during disturbances of delivery. Transition into the mode of dynamic Tendography (Hartert) will e.g. register all fast going tests lasting minutes or seconds. It is comparable to an accelerated form of Thrombelastography (Hartert), the intercourse of which with coagulum yet is an exclusively static operation. Another category is measurement of blood and plasma viscosity. In concentrated blood it seizes plasticity of blood cells as well as their intensity of aggregation in orbital flow. The latest methodical development of Orbitometry is control of platelet activity in its function of adhesion. This is realized by measurement of specific physical effects released in platelet containing coagulum. They generate a structural degradation of fibrin elasticity modul as well as a tendency for coagulum adhesion. The practical use of Adhesiography is control of anticoagulants and platelet protecting substances in their quantitative influence on coagulum structure and on the mentioned platelet activities. A special disturbance of these platelet depending mechanisms obviously is getting evidence in case of v.Willebrand’ s syndrome.

Keywords: Orbitometer, fibrin elasticity, strain of flow, resonance, adhesiography, platelet shape change

DOI: 10.3233/BIR-1990-27613

Journal: Biorheology, vol. 27, no. 6, pp. 921-929, 1990