Tube flow of human blood at near zero shear

Article type: Research Article

Authors: Gaehtgens, P.

Affiliations: Freie Universität Berlin, Dept. of Physiology, Arnimallee 22, D-1000 Berlin 33, FRG

Note: [] Accepted by: Editor D. Quemada

Abstract: Pressure-velocity relations were obtained in vertical and horizontal glass tubes (I.D. 26 to 83 μm) perfused with normal human blood at feed hematocrits between 0.25 and 0.65. Perfusion pressures used corresponded to wall shear stresses up to 0.27 dyn cm−2 Red cell velocity measurements were made both immediately following implementation of perfusion pressure (with red cells still desaggregated) and in a steady state situation (with red cells aggregated). Analysis of the slopes of the linear relations between perfusion pressure and velocity showed apparent viscosity to decrease with the manifestation of red cell aggregation. In horizontal tubes, sedimentation and aggregation occurred simultaneously, and apparent viscosity increased due to axial asymmetry of cell concentration. Evidence for a yield shear stress (flow stagnation at positive driving pressure) was not observed.

Keywords: viscosity, aggregation, sedimentation, yield stress

DOI: 10.3233/BIR-1987-24402

Journal: Biorheology, vol. 24, no. 4, pp. 367-376, 1987