Mechano-mathematical model of excitation-contraction coupling in muscle tissue

Issue title: New Methods in Biorheology. Proceedings of the International Symposium held in Nancy, France, 17–18 August 1983. A Satellite Symposium of the Fifth International Congress of Biorheology

Guest editors: J.F. Stoltz and E. Puchelle

Article type: Research Article

Authors: Mihailova, A.P.^a | Petrov, N.K.^b

Affiliations: [a] OBI, Centre of Biology, Bulgarian Academy of Sciences, Acad. G.Bonchev Str. bl. 23, Sofia 1113, Bulgaria | [b] Institute of Mechanics and Biomechanics, Bulgarian Academy of Sciences, Acad. G.Bonchev Str. bl. 8, Sofia 1113, Bulgaria

Abstract: A system of equations, describing the excitation-contraction coupling in cardiac muscle is obtained on the basis of a physiological model and of a thermodynamical one of a system with external control, the latter model being proposed by the authors. A single isometric contraction is modelled for latent, activation and relaxation periods. The obtained theoretical results coincide qualitatively with the experimental data.

Keywords: thermodynamic model, cardiac muscle tissue, excitation-contraction coupling

DOI: 10.3233/BIR-1984-23S135

Journal: Biorheology, vol. 23, no. s1, pp. 209-212, 1984