Initial filtration rate and initial clogging in the hemorheometre

Article type: Research Article

Authors: Matrai, A.^a | Reid, H.^b | Bogar, L.^a | Flute, P.T.^a | Dormandy, J.A.^a

Affiliations: [a] St. James’ and St. George’s Hospitals, London1 | [b] Univ. of Benin, Benin, Nigeria

Note: [] Accepted by: Editor C.G. Caro

Abstract: The role of different factors contributing to red cell filterability in the Hemorheometre has been investigated. Although the original method uses a small volume of suspension to determine red cell filterability, the present experiments showed that the results obtained are still significantly affected by filter clogging. Consequently a change 1n filterability could be due to a change in filter clogging possibly by residual leucocytes. An adaptation of filter chamber and filling method is described, resulting 1n a simpler and faster measuring procedure. The inaccuracy in measuring low haematocrits contributes significantly to experimental errors. Therefore a definition of red cell filterability based on the red cell count (instead of haematocrit) of the suspension is suggested.

Keywords: red cells, deformability, filtration, filter clogging

DOI: 10.3233/BIR-1985-22401

Journal: Biorheology, vol. 22, no. 4, pp. 275-284, 1985