You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

Joint Meeting of the The European Society for Clinical Hemorheology and Microcirculation The International Society for Clinical Hemorheology The International Society of Biorheology July 4–7, 2021

July 4, 2021
14:30–15:30Opening Ceremony
15:40–16:40Opening Plenary Lecture
Chair: Shinya Goto
PL1Coagulopathy and Anticoagulation in Covid-19 - what can we learn for future challenges?
Danial Dürschmied
Cardiology and Intensive Care Medicine, Heart Center, University of Freiburg, Germany
16:50–17:50 Plenary Lecture for ESCHM
Chair: Jean-Frederic Brun
PL2Lessons learnt from comparative hemorheology
Ursula Windberger
Medizinische Universitaet Wien, Center for Biomedical Research
18:00–19:00 Rising Star Award Session - 1
Chairs: Maria Fornal, Ursula Windberger
RSA1-1Towards elimination of sublethal blood trauma in mechanical circulatory support
Michael J Simmonds 1,2
1 Menzies Health Institute Queensland, 2 Griffith University, Australia
RSA1-2Hemorheological changes caused by pituitary adenylate cyclase-activating polypeptide administration during vessel anastomosis regeneration in the rat
Balazs Szabo 1, Laszlo Adam Fazekas 1, Adam Varga 1, Barbara Barath 1, Vince Szegeczki 2, Tamas Juhasz 2, Dora Reglodi 3, Norbert Nemeth 1
1 Department of Operative Techniques and Surgical Research, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, 2 Department of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen Hungary, 3 Department of Anatomy, Faculty of Medicine, University of Pecs, Pecs, Hungary
19:00–20:20Free Communication (Video Presentation 1)
20:20–21:50 Symposia S1–S3
S1: Microperfusion of different inner organs examined by contrast enhanced ultrasound technology or PET/CT
Chair: Dong Yi
S1-1Potential application of dynamic contrast enhanced ultrasound in predicting microvascular invasion of hepatocellular carcinoma
Yi Dong 1, Yijie Qiu 1, Daohui Yang 1, Dan Zuo 1, Qi Zhang 1, Wen-Ping Wang 1, Ernst Michael Jung 2
1 Zhongshan Hospital, Fudan University, 2 Department of Radiology, University Medical Center Regensburg, Germany
S1-2[Withdrawn]
S1-3[Withdrawn]
S2: Clinical hemorheology in critically ill patients
Chairs: Shohei Moriyama, Michinari Hieda, Masahito Hitosugi
S2-1Vascular toxicity in cardio-oncology
Shohei Moriyama, Michinari Hieda
Department of Hematology, Oncology and Cardiovascular Medicine, Kyushu University Hospital
S2-2Catheter treatment of leg arterial atherosclerosis: Endovascular treatment for peripheral arterial disease
Eiji Karashima
Shimonoseki City Hospital
S2-3Advances in diagnosis and treatment of pulmonary hypertension
Kohtaro Abe
Department of Cardiovascular Medicine, Kyushu University Hospital
S2-4Myocardial pathological changes in patients with epilepsy and psychiatric disorders
Marin Takaso, Misa Tojo, Masahito Hitosugi
Department of Legal Medicine, Shiga University of Medical Science
S3: Intracellular signaling in RBC: roles and consequences
Chairs: Özlem Yalçın, Philippe Connes
S3-1Calcium signaling in red cells induced by mechanical stress and flow
Lars Kaestner
Saarland University
S3-2Shear conditioning attenuates the effects of superoxide in red blood cells: Role of generation and signaling of nitrogen species in different cell subpopulations
Marijke Grau 1, Lennart Kuck 2, Thomas Dietz 1, Michael J Simmonds 2
1 German Sport University Cologne, Institute of Cardiovascular Research and Sports Medicine, 2 Griffith University Mechanobiology Research Laboratory
S3-3Signaling in erythroid cells: Role in physiology and contribution to pathological manifestations
Wassim El Nemer
EFS
S3-4Impact of oxidative stress and decreased NO bioavailability on eryptosis and red blood cell microparticles in SCA: Consequences on endothelial cells and vascular function
Elie Nader 1,2, Marc Romana 3,4, Nicolas Guillot 1,2, Romain Fort 5, Emeric Stauffer 1,2,6, Nathalie Lemonne 7, Yohann Garnier 3,4, Sarah Skinner 1,2, Maryse Etienne-Julan 7, Mélanie Robert 1,2,8, Alexandra Gauthier 1,2,9, Giovanna Cannas 5, Sophie Antoine-Jonville 3, Benoit Tressières 10, Marie-Dominique Hardy-Dessources 3,4, Yves Bertrand 9, Céline Renoux 1,2,11, Philippe Joly 1,2,11, Marijke Grau 12, Philippe Connes 1,2
1 Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team “Vascular Biology and Red Blood Cell”, Université Claude Bernard Lyon, Université de Lyon, Lyon, France, 2 Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, 3 Université des Antilles, Pointe-à-Pitre, France, 4 Université de Paris, Paris, France, 5 Département de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, Lyon, France, 6 Centre de Médecine du Sommeil et des Maladies Respiratoires, Hospices Civils de Lyon, Hôpital de la Croix Rousse, Lyon, France, 7 Unité Transversale de la Drépanocytose, Hôpital de Pointe-à-Pitre, Hôpital Ricou, Guadeloupe, France, 8 Erytech Pharma, Lyon, France, 9 Institut d’Hématologie et d’Oncologie Pédiatrique, Hospices Civils de Lyon, Lyon, France, 10 Centre Investigation Clinique Antilles Guyane, 1424 Inserm, Academic Hospital of Pointe-à -Pitre, Guadeloupe, France, 11 Laboratoire de Biochimie et de Biologie Moléculaire, UF de Biochimie des Pathologies érythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, Lyon, France, 12 Molecular and Cellular Sport Medicine, Deutsche Sporthochschule Köln, Köln, Germany
S3-5Phosphoproteomic changes in red blood cell membrane by Adenyly cyclase/Protein kinase A signaling pathway and their roles on the mechanical stress responses of red blood cells
Elif Ugurel 1,2, Neslihan Cilek 1,2, Evrim Goksel 1,2, Ozlem Yalcin 1,2
1 Koc University School of Medicine Department of Physiology, 2 Koc University Research Center for Translational Medicine
July 5, 2021
09:10–10:10 Keynote Lecture 1
Chair: Toru Maruyama
KL1Endothelium-dependent hyperpolarization (EDH) and endothelial dysfunction in hypertension: The role of endothelial ion channels
Kenichi Goto
Kyushu University
09:10–10:10 Keynote Lecture 2
Chair: Takeshi Nakatani
KL2Clinical management for adverse complications in patients with left ventricular assist devices
Michinari Hieda
Kyushu University
09:10–10:40 Symposium S4
S4: Microfluidic and in silico device applications in hemorheology
Chairs: Sara Hashmi
S4-1Microfluidic assays to investigate the role of red blood cell-derivedextracellular vesicles in sickle cell disease
Ran An An, Umut Gurkan
Case Western Reserve University
S4-2Hemorheology and pathophysiology of COVID-19 induced thrombosis predicted by Vein-Chip
Navaneeth Krishna Rajeeva Pandian, Abhishek Jain
Texas A&M University
10:20–11:50 Symposia S5–S6
S5: Mechanical circulatory support: From in-development to in vivo
Chairs: Michael Simmonds, Tamas Alexy
S5-1The importance of blood rheology in left ventricular assist device therapy
Mohammed Chowdhury 1, Valmiki Maharaj 2, Arianne Agdamag 2, Blair Edmiston 3, Bellony Nzemenoh 3, Victoria Charpentier 4, Tamas Alexy 2
1 North Central Heart, Sioux Falls, SD, USA, 2 Department of Medicine, Division of Cardiology, University of Minnesota, MN, USA, 3 Department of Medicine, University of Minnesota, MN, USA, 4 University of Minnesota Medical School, Minneapolis, MN, USA
S5-2Hemo-compatibility related adverse events with left ventricular assist device (LVAD) support: Past, present, and future
Valmiki Maharaj 1, Mohammed Chowdhury 2, Arianne Agdamag 1, Blair Edmiston 3, Bellony Nzemenoh 3, Victoria Charpentier 4, Tamas Alexy 1
1 Department of Medicine, Division of Cardiology, University of Minnesota, MN, USA, 2 North Central Heart, Sioux Falls, SD, USA, 3 Department of Medicine, University of Minnesota, MN, USA, 4 University of Minnesota Medical School, Minneapolis, MN, USA
S5-3Analysis of the HeartMate 3 pump characteristics under continuous and pulsatile flow operation – An in vitro study
Jo Pauls 1,2, Nicole Bartnikowski 2,3, E-Peng Seah 2, Clayton Semenzin 2, Martin Mapley 2
1 Griffith University - School of Engineering and Built Environment, 2 Innovative Cardiovascular Engineering and Technology Laboratory, Critical Care Research Group, The Prince Charles Hospital, 3 Queensland University of Technology - Science and Engineering Faculty
S5-4Re-evaluation of blood trauma from a sublethal perspective
Michael J Simmonds 1,2
1 Menzies Health Institute Queensland, 2 Griffith University, Australia
S6: Multi-scale diagnosis of biorheology and microcirculation
Chairs: Yu Nakamichi, Daisuke Furukawa
S6-1Micro-tomographic visualization of tissue rheological properties by mechanical stimulation using optical coherence tomography
Daisuke Furukawa 1, Souichi Saeki 2
1 Akita Prefectural University, Faculty of Systems Science and Technology, 2 Meijo University, Graduate School of Science and Technology
S6-2Three-dimensional detection of hemodynamic changes in skin microcirculation by optical coherence tomography-angiography
Yu Nakamichi
Sanyo-Onoda City University
S6-3Investigation the extensional effects on the viscosity distribution of bile in the cystic duct
Ngoc Minh Nguyen 1, Hiromichi Obara 2
1 Department of Mechanical Engineering, Thuyloi University, 175 Tay Son, Dong Da, Ha Noi, Vietnam, 2 Department of Mechanical Systems Engineering, Tokyo Metropolitan University, 1-1 Minami Osawa, Hachioji, Tokyo, Japan
S6-4Quantitative evaluation of flowing blood with the electrical parameters based on the Hanai mixture equation
Yusuke Nakajima 1, Daisuke Kawashima 1, Ryubu Shoji 1, Katsuhiro Matsuura 2, Masahiro Takei 1
1 Division of Mechanical Engineering, Chiba University, 2 Department of Veterinary Surgery, Tokyo University of Agriculture and Technology
S6-5Development of butterfly type artificial atrioventricular valve with anisotropic valvular cusps by using collagenous connective tissue membrane “Biosheet®” similar to in vivo tissue architecture
Yota Sekido 1, Yasuhide Nakayama 2, Tsutomu Tajikawa 3
1 Kansai University, Graduate School of Science and Engineering, 2 Biotube Co., Ltd, 3 Kansai University, Faculty of Engineering Science
12:00–13:00 President-Invited Plenary Lecture - 1
Chair: Toshiro Ohashi
PL3On the path of cell biomechanics research
Masaaki Sato
Tohoku University
14:20–15:50 Symposia S7–S9
S7: Whole blood behaviour in chips, stents and capillaries
Chairs: Andreas Passos, Efstathios Kaliviotis
S7-1Investigation of hemorheological and hematological properties of blood in stented mice
Despoina Kokkinidou 1,2, Konstantinos Kapnisis 2, Efstathios Kaliviotis 1, Andreas Anayiotos 2
1 Biorheology Laboratory, Dept. of Mechanical Engineering and Material Science ad Engineering, Cyprus University of Technology, Cyprus, 2 BioLISYS Laboratory, Dept. of Mechanical Engineering and Material Science ad Engineering, Cyprus University of Technology, Cyprus
S7-2Estimation of whole blood coagulation using image processing techniques
Marinos Louka 1, Antonios Inglezakis 2, Constantinos Loizou 2, Savvas Psarelis 3, Elena Nikiphorou 4, Efstathios Kaliviotis 1
1 Cyprus University of Technology, 2 EMBIO Diagnostics Ltd, Nicosia, Cyprus, 3 Ministry of Health Cyprus, Nicosia, Cyprus, 4 King’s College London, King’s College Hospital, London, UK
S7-3Capillary blood flow on a chip: Influence of hemorheological factors.Capillary blood flow on a chip: Influence of hemorheological factors.
Dimitris Pasias Pasias, Andreas Passos, Georgios Constantinides, Loukas Koutsokeras, Stavroula Balabani, Efstathios Kaliviotis
Cyprus University of Technology
S7-4Erythrocyte sedimentation rate measurements in a high aspect ratio microfluidic channel
Andreas Passos 1, Antonis Nikolaidis 1, Charalampos Vryonidis 1, Konstantinos Loizou 2, Antonis Inglezakis 2, Efstathios Kaliviotis 1
1 Dept. of Mechanical Engineering and Material Science and Engineering, Cyprus University of Technology, Cyprus, 2 EMBIO Diagnostics Ltd, Nicosia, Cyprus
S7-5Influence of hemorheological parameters on the local velocity characteristics of blood in a superehydrophylic channel
Efstathios Kaliviotis 1, Dimitris Pasias 1, Andreas Passos 1, Loukas Koutsokeras 1, Georgios Constantinides 1, Stavroula Balabani 2
1 Cyprus University of Technology, 2 University College London
S8: Mechanobiology of red blood cells
Chairs: Michael Simmonds, Jon Detterich
S8-1Role of Piezo1 in red blood cell sickling
Elie Nader 1,2,3, Aline Hatem 4, Robin Bertot 1, Philippe Joly 1,2,3, Camille Boisson 1,2,3, Guillaume Bouyer 4, Nicolas Guillot 1,2,3, Alexandra Gauthier 1,2,3, Solène Poutrel 1,2,3, Céline Renoux 1,2,3, Nicola Conran 5, Flavia Costa 5, Yves Bertrand 3, Stéphane Égée 4, Philippe Connes 1,2,3
1 Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team Vascular Biology and Red Blood Cell, Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France, 2 Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, 3 Reference Center in Sickle cell disease, Thalassemia and rare red blood cell and erythropoiesis diseases, Hospices Civils de Lyon, Lyon, France, 4 UMR 8227 CNRS-Sorbonne Université, Station Biologique, Place Georges Teissier, BP 74, 29682 Roscoff Cedex, France, 5 Hematology Center, University of Campinas – UNICAMP, Cidade Universitária, Campinas-SP, Brazil
S8-2Shear induced red blood cell nitric oxide production is increased in sickle cell disease
Jon A Detterich 1,2, Silvie Suriany 1, Honglei Liu 1, Pinar Ulker 3, G Esteban Fernandez 1, Matthew Borzage 1, Rosalinda Wenby 2, Herbert J Meiselman 2, Henry J Forman 4, Thomas D Coates 1
1 Children’s Hospital of Los Angeles, 2 Keck School of Medicine, University of Southern California, 3 Department of Physiology, Akdeniz University, 4 Department of Gerontology, University of Southern California
S8-3Contribution of red blood cells to pulmonary arterial hypertension pathogenesis: NOS activity and vessel responses
Pinar Ulker 1, Ibrahim Basarici 2, Nur Özen 1, Ece Kilavuz 1, Fatih Kisak 1, Filiz Basrali 1, Nazmi Yaras 3, Sadi Koksoy 4, Mukadder Levent Celik 5, Leyla Abueid 1, Ahmet Yildirim 1
1 Department of Physiology, Medical Faculty, Akdeniz University, Antalya, Turkey, 2 Department of Cardiology, Medical Faculty, Akdeniz University, Antalya, Turkey, 3 Department of Biophysics, Medical Faculty, AkdenizUniversity, Antalya, Turkey, 4 Department of Medical Microbiology, Medical Faculty, AkdenizUniversity, Antalya, Turkey, 5 Department of Internal Medicine, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey.
S8-4Impaired mechanotransduction in diamide-treated erythrocytes
Lennart Kuck 1, Jason N. Peart 2, Michael J. Simmonds 1
1 Biorheology Research Laboratory, Menzies Health Institute, Griffith University Gold Coast, Queensland, Australia, 2 School of Medical Science, Griffith University Gold Coast, Queensland, Australia
S9: Hemorheological Measurement and Analysis: RBCs and Platelets
Chairs: Sehyun Shin, Dong-Guk Paeng
S9-1Deformability measurement of RBCs flowing in capillary channels using a coflowing channels-based pressure sensor
Yang Jun Kang 1, Sami Serhrouchni 2, Anna Bogdanova 2, Sung-Sik Lee 3
1 Chosun University, 2 University of Zürich, 3 ETH Zürich
S9-2Numerical study of local parabolic rouleaux formation analyzed by axial and radial shear rates
Cheong-Ah Lee 1, Dong-Guk Paeng 1,2
1 Jeju National University, 2 University of Virginia
S9-3Total volume ratio (TVR): A new parameter to evaluate the risk of aneurysm rupture
Jinmu Jung 1, Ui Yun Lee 1, Hyosung Kwak 2, Dongwhan Lee 1
1 Division of Mechanical Design Engineering, College of Engineering, Jeonbuk National University, Jeonju, South Korea, 2 Department of Radiology, Jeonbuk National University Hospital, Jeonju, South Korea
S9-4Measurement of platelet adhesion by using correlation mapping
Eunseop Yeom
Pusan National University
S9-5Thrombus formation through upstream activation and downstream adhesion of platelets in a microfluidic system
Sehyun Shin 1, SeonYoung Kim 2, ByoungKwon Lee 3, ChaeSeung Lim 4
1 Korea University, 2 Rheomeditech. Inc., 3 Gangnam Severance Hospital, Yeonsei University, 4 Guro Hospital, Korea University
16:00–17:30 Symposia S10–S12
S10: Rheological models and estimation of prognosis in clinical hemorheology
Chairs: Kalman Toth, Peter Kenyeres
S10-1Hemorheological alterations in patients with chronic cerebrovascular disease
Peter Kenyeres 1, Kinga Totsimon 1, Alexandra Nagy 3, Barbara Sandor 1, Katalin Biro 1, Laszlo Szapary 2, Kalman Toth 1, Zsolt Marton 1
1 1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, 2 Department of Neurology, University of Pecs, Medical School, Pecs, Hungary, 3 Department of Behavioral Sciences, University of Pecs, Medical School, Pecs, Hungary
S10-2Novel predictors of future vascular events in post-stroke patients
Diana Schrick 1, Erzsebet Ezer 1, Margit Tokes-Fuzesi 2, Tihamer Molnar 1
1 Department of Anaesthesiology and Intensive Therapy, University of Pecs, Medical School, Pecs, Hungary, 2 Department of Laboratory Medicine, University of Pecs, Medical School, Pecs, Hungary
S10-3Hemorheological investigations in critically ill patients
Zsolt Marton, Zsofia Eszter Szabo, Kinga Totsimon, Kalman Toth, Peter Kenyeres
1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary
S10-4Maternal hemorheological changes in early-onset preeclampsia
Beata Csiszar 1,2, Gergely Galos 1,2, Peter Kenyeres 1,2, Kalman Toth 1,2, Barbara Sandor 1,2
1 1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, 2 Szentagothai Research Centre, Pécs, Hungary
S10-5The French paradox - from a rheological point of view
Andras Toth 1,2, Barbara Sandor 2, Judit Papp 2,3, Miklos Rabai 2, Peter Kenyeres 2, Istvan Juricskay 2, Kalman Toth 2
1 Department of Medical Imaging, University of Pecs, Medical School, Pecs, Hungary, 2 1st Department of Medicine, University of Pecs, Medical School, Pecs, Hungary, 3 Hungarian Defence Forces Medical Centre, Budapest, Hungary
S10-6Hemorheological, hematological and histological examination, and 3D flow simulation of arterio-venous fistulas or loop-shaped venous grafts in the rat
Balazs Szabo 1, Adam Varga 1, Barbara Barath 1, Souleiman Ghanem 1, Orsolya Matolay 2, GyorgyTrencseny 3, Levente Kiss-Papai 5, Balazs Gasz 5, Lajos Daroczi 4, Norbert Nemeth 1
1 Department of Operative Techniques and Surgical Research, University of Debrecen, Faculty of Medicine, Debrecen, Hungary, 2 Department of Pathology, Faculty of medicine, University of Debrecen, Debrecen, Hungary, 3 Division of Nuclear Medicine, Department of Medical Imaging, Faculty of medicine, University of Debrecen, Debrecen, Hungary, 4 Institute of Physics, Department of Solid State Physics, Faculty of Physics, University of Debrecen, Debrecen, Hungary, 5 Department of Surgical Research and Techniques, Faculty of Medicine, University of Pecs, Hungary
S11: Known and unknown factors regulating the circulatory system
Chairs: Kvetoslava Burda, Maria Fornal
S11-1Association of sulfur concentration in erythrocytes with heart geometry parameters and blood pressure
Maria Fornal 1, Janusz Lekki 2, Jarosław Krolczyk 1, Barbara Wizner 1, Tomasz Grodzicki 1
1 Jagiellonian University Medical College, Krakow, Poland, 2 Institute of Nuclear Physics PAN, Krakow, Poland
S11-2Results of blood research relating to: rheology, morphology and biochemistry of blood in a man living 50 days in extremely low temperatures
Zbigniew Joseph Dabrowski 1, Aneta Teleglow 1, Anna Marchewka 1, Maria Fornal 2
1 Academy of the Physical Education in Cracow, Poland, 2 Collegium Medicum, Jagiellonian University, Krakow, Poland
S11-3Interactions of 𝛽-carotene with red blood cells - its effect on their stability and functioning
Joanna Fiedor 1, Mateusz Przetocki 1, Aleksander Siniarski 2,3, Grzegorz Gajos 2,3, Nika Spiridis 4, Kinga Freindl 4, Kvetoslava Burda 1
1 AGH University of Science and Technology, Faculty of Physics and Applied Computer Science, Krakow, Poland, 2 Jagiellonian University Medical College, Krakow, Poland, 3 The John Paul II Hospital, Krakow, Poland, 4 Polish Academy of Sciences, Krakow, Poland
S11-4Correlations between hemorheological parameters in a group of qualified honorary blood donors compared to those in a group of cardiovascular patients.
Anna Marcinkowska-Gapinska
Department of Biophysics, Karol Marcinkowski University of Medical Sciences in Poznan, Poland
S11-5Can nanoparticles be responsible for the development of hypertension?
Kvetoslava Burda 1, Joanna Fiedor 1, Magdalena Peter 1, Mateusz Przetocki 1, Jaroslaw Kiecana 2,3, Aleksander Siniarski 2,3, Grzegorz Gajos 2,3, Nika Spiridis 4
1 AGH-University of Science and Technology, Krakow, Poland, 2 The John Paul II Hospital, Krakow, Poland, 3 Jagiellonian University, Medical College, Krakow, Poland, 4 Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Krakow, Poland
S12: Colloidal models in red blood cell behaviour
Chairs: Alexis Darras, Alexander Pribush
S12-1Intricate journey of micro- and nano-carriers for drug delivery in the blood stream
Dmitry Fedosov
Forschungszentrum Juelich GmbH
S12-2Physical mechanism of erythrocytes sedimentation: experiments and gel-model
Alexis Darras 1, Anil Kumar Dasanna 2, Thomas John 1, Gerhard Gompper 2, Lars Kaestner 1, Dmitry A. Fedosov 2, Christian Wagner 1
1 Experimental Physics, Saarland University, 66123 Saarbruecken, Germany, 2 Theoretical Physics of Living Matter, Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany
S12-3The erythrocyte sedimentation rate as a diagnostic biomarker for neuroacanthocytosis syndromes
Alexis Darras 1, Kevin Peikert 2,3, Antonia Rabe 1,4, François Yaya 1,5, Greta Simionato 1,6, Thomas John 1, Anil Kumar Dasanna 7, Semen Bavalyy 7, Jürgen Geisel 8, Andreas Hermann 2,3,9,10, Dmitry A. Fedosov 7, Adrian Danek 11, Christian Wagner 1,12, *Lars Kaestner 1,4
1 Experimental Physics, Saarland University, 66123 Saarbruecken, Germany, 2 Translational Neurodegeneration Section “Albrecht-Kossel”, Department of Neurology, University Medical Center Rostock, University of Rostock, Rostock, Germany, 3 Neurodegenerative Diseases, Department of Neurology, Technische Universität Dresden, Dresden, Germany, 4 Theoretical Medicine and Biosciences, Saarland University, 66424 Homburg, Germany, 5 Laboratoire Interdisciplinaire de Physique, UMR 5588, 38402 Saint Martin d’Hères, France, 6 Institute for Clinical and Experimental Surgery, Saarland University, 66424 Homburg, Germany, 7 Institute of Biological Information Processing and Institute for Advanced Simulation, Forschungszentrum Jülich, 52425 Jülich, Germany, 8 Central Clinical Laboratory, Saarland University, 66424 Homburg, Germany, 9 DZNE, German Center for Neurodegenerative Diseases, Research Site Rostock/Greifswald, Rostock, Germany, 10 Center for Transdisciplinary Neurosciences Rostock (CTNR), University Medical Center Rostock, University of Rostock, Rostock, Germany, 11 Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, 81366 Munich, Germany, 12 Physics and Materials Science Research Unit, University of Luxembourg, Luxembourg City, Luxembourg
S12-4Investigating the red blood cells (dis)aggregation mechanisms by means of optical tweezers
*Francois Yaya 1,2, Olivera Korculanin 3,4, Mehrnaz Babaki 3,4, Pavlik Lettinga 3,4, Christian Wagner 1, Kisung Lee 5
1 Experimental Physics, University of Saarland, Saarbrücken, Germany, 2 Laboratoire Interdisciplinaire de Physique (LIPhy), CNRS and University of Grenoble, Grenoble, France, 3 Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Jülich GmbH, Jülich, Germany, 4 Laboratory for Soft Matter and Biophysics, KU Leuven, Leuven, Belgium, 5 Center for Soft and Living Matter, Institute for Basic Science, Ulsan, South Korea
17:50–18:50 President-Invited Plenary Lecture - 2
Chair: Alberto Caggiati
PL4Pathophysiology and treatment options for venous ulceration: Is there a role for exercise?
Markos Klonizakis
Lifestyle, Exercise and Nutrition Improvement (LENI) Research Group, Department of Nursing and Midwifery, Sheffield Hallam University, United Kingdom
19:00–20:00 Plenary Lecture for ISCH
Chair: Brian Cooke
PL5Hemodynamic functionality of transfused red blood cells – A0 potent effector of transfusion outcome
*Saul Yedgar 1, Neta Goldschmidt 2, Orly Zelig 2, Axel Pries 3, Gregory Barshtein 1
1 The Hebrew University Medical School, Jerusalem, Israel, 2 Hadasah Hospital, Jerusalem, Israel, 3 Charite-Free University, Berlin, Germany
20:10–21:40 Symposia S13–S15
S13: Preclinical and clinical studies on blood cells and microcirculation
Chair: Anna Maria Blocki
S13-1Nanoparticle-mediated delivery of nucleic acids in primary human endothelial cells
Manfred Gossen 1,2, Skadi Lau 1,2, Hanieh Moradian 1,2,3, Marc Behl 1, Andreas Lendlein 1,2,3
1 Institute of Active Polymers, Helmholtz-Zentrum Hereon, Teltow, Germany, 2 Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Berlin, Germany, 3 Institute of Biochemistry and Biology, University of Potsdam, 14476 Potsdam, Germany
S13-2Long-term stabilization of three-dimensional perfusable microvascular networks in microfluidic devices
Ho-Ying Wan 1, Jack Chun Hin Chen 2, Qinru Xiao 2, Christy Wingtung Wong 1, Yi-Ping Megan Ho 2, Roger D. Kamm 3, Sebastian Beyer 2, Anna Maria Blocki 1
1 Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, 2 Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, 3 Department of Biology and Mechanical Engineering, Massachusetts Institute of Technology
S13-3[Withdrawn]
S13-4Assessment of leukocyte activation in the intestinal microcirculation in a novel model of CNS injury-induced immunodepression
Bashir Bietar, Christian Lehmann
Dalhousie University
S13-5Experimental Cannabinoid Receptor 2 Modulation for the Treatment of Interstitial Cystitis
Geraint Christopher Berger 1, Juan Zhou 1, Melanie Kelly 2,1,4, Christian Lehmann 1,2,3,5
1 Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 2 Department of Pharmacology, Dalhousie University, 3 Department of Microbiology & Immunology, Dalhousie University, 4 Department of Ophthalmology & Visual Sciences, Dalhousie University, 5 Department of Physiology and Biophysics, Dalhousie University
S14: Biorheology and COVID-19 Thrombosis
Chairs: Barbara Zieger, Shinya Goto
S14-1[Withdrawn]
S14-2Retrospective study of COVID-19-associated coagulopathy in hospitalized patients at Tokai University Hospital
Masayuki Oki 1, Hideki Yanagi 1, Masahiro Kamono 1, Saki Manabe 1, Akiko Taoda 1, Ayumi Tsuda 1, Satoshi Abe 1, Takako Kobayashi 1, Koichiro Asano 2, Yoshihide Nakagawa 1, Yasuhiro Kanatani 3, Hideki Ozawa 1, Shinya Goto 2
1 Department of General Medicine, Tokai University School of Medicine, 2 Department of Internal Medicine, 3 Department of Pharmacology
S14-3COVID-19 and thrombosis: the importance of endothelial function.
Shinichi Goto 1,2,3, Shinya Goto 3
1 Brigham and Women’s Hospital, Harvard Medical School, 2 Keio University School of Medicine, 3 Tokai University School of Medicine
S15: New useful techniques in disease
Chairs: Özlem Yalçın, Philippe Connes
S15-1A novel integrated biomarker for screening diabetic kidney diseases: critical shear stress of RBCs
Sehyun Shin 1, Junsung Moon 2, Jimi Choi 3, Sin-Gon Kim 3, Kyu Jang Won 2
1 Korea University, 2 Yeungnam University Hospital, 3 Korea University Anam Hospital
S15-2Clinical microfluidic biomarker assays for red cell health and blood rheology
Umut Gurkan
Case Western Reserve University
S15-3Concurrent assessment of deformability and adhesiveness of sickle red blood cells by measuring perfusion of an adhesive artificial microvascular network
Madeleine Lu 1, Celeste Kanne 2,3, Riley Reddington 1, Dalia Lezzar 1, Vivien Sheehan 2,3, *Sergey Shevkoplyas 1
1 Department of Biomedical Engineering, University of Houston, Houston, TX, USA, 2 Aflac Cancer and Blood Disorders Center, Children’s Healthcare of Atlanta, Atlanta, GA, USA, 3 Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
S15-4Usefulness of oxygen gradient ektacytometry in sickle cell disease
Philippe Connes 1,2, Camille Boisson 1,2,3, Minke Rab 4,5, Elie Nader 1,2, Céline Renoux 1,2,3, Philippe Joly 1,2,3, Romain Fort 1,2,6, Alexandra Gauthier 1,2,7, Yves Bertrand 7, Richard van Wijk 4, Vivien Sheehan 8, Eduard van Beers 5
1 Laboratoire Interuniversitaire de Biologie de la Motricite (LIBM) EA7424, Team Vascular Biology and Red Blood Cell, Universite Claude Bernard Lyon 1, Universite de Lyon, France, 2 Laboratoire d’Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, Paris, France, 3 Laboratoire de Biochimie et de Biologie Moleculaire, Lyon, 4 Central Diagnostic Laboratory - Research, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, 5 Van Creveldkliniek, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands, 6 Departement de Meedecine Interne, Hopital Edouard Herriot, Hospices Civils de Lyon, 7 Institut d’Hematologie et d’Oncologie Pediatrique, Hospices Civils de Lyon, Lyon, 8 Department of Pediatrics, Division of Hematology/Oncology, Baylor College of Medicine; Houston Texas, USA
S15-5A novel microfluidics-based point of care technique for viscoelastic hemostatic assay
*Ozlem Yalcin 1, Ahmet Can Erten 2, Berfin Irmak Torun 3, Fatma Oz 3
1 Koc University, School of Medicine, Koç University, Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey, 2 Department of Electronics and Communication Engineering, Istanbul Technical University, Istanbul, Turkey, 3 Koç University, Graduate School of Biomedical Sciences and Engineering, Istanbul, Turkey
July 6, 2021
9:10–10:10 Rising Star Award Session – 2
Chair: Edgar O’Rear, Tamas Alexy
RSA2-1Blood flow thrombosis simulation to understand complex phenomenon of thrombosis under blood flow conditions
Shinichi Goto 1, Noriko Tamura 3, Masamitsu Nakayama 2, Shu Takagi 4, Shinya Goto 2
1 Brigham and Women’s Hospital, Harvard Medical School, MA, USA, 2 Tokai University School of Medicine, Japan, 3 Niigata University of Health and Welfare, Japan, 4 Graduate School of Engineering, The University of Tokyo, Japan
RSA2-2Suspension rheology of red blood cells under oscillatory shear flow
Naoki Takeishi 1, Marco E Rosti 2, Naoto Yokoyama 3, Shigeo Wada 1, Luca Brandt 4
1 Osaka University, 2 OIST, 3 Tokyo Denki University, 4 KTH
10:20–11:20Free Communication (Video Presentation 2)
11:30–12:30 Plenary Lecture for ISB
Chair: Peter Butler
PL6Lessons from red blood cell mechanics to endothelial cell mechanobiology
Kris N. Dahl
Carnegie Mellon University
13:50–14:50 Keynote Lecture 3
Chair: Toshiaki Dobashi
KL3Coagulation of blood: A possible triggering mechanism of the intrinsic coagulation pathway, and assessment of anticoagulant effect of DOACs using a seesaw-type device
Makoto Kaibara 1, Hiroshi Ujiie 2
1 Past affiliation: RIKEN (The Inst. Phys. Chem. Res.), 2 Ujiie Neurosurgical & Medical Clinic
13:50–14:50 Keynote Lecture 4
Chair: Nobuo Watanabe
KL4Computational fluid dynamics (CFD) analysis to optimize the design of rotary blood pumps
Masahiro Nishida
National Institute of Advanced Industrial Science and Technology
13:50–14:50Keynote Lecture 5
Chair: Toru Maruyama
KL5Dynamics of blood fluidity under various pathologic conditions. The roles of endothelial anticoagulant activities and their pathophysiologic conditions
Ikuro Maruyama
Department of Systems Biology in Thromboregulation, Kagoshima University Graduate School of Medical and Dental Sciences
15:00–16:30Symposia S16-S17 / Free Communication (Live presentation) O1
S16: Hemorheological and metabolic properties of red blood cells
Chairs: Björn Neu, Olivera Korculanin
S16-1Competition between red blood cell aggregation and breakup: Depletion force due to filamentous viruses vs. shear flow
Olivera Korculanin 1,2, Tatiana Kochetkova 1, Pavlik Minne Paul Lettinga 1,2
1 Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Juelich GmbH, Germany, 2 Laboratory for Soft Matter and Biophysics, KU Leuven, Belgium
S16-2Sphingosine-1-phosphate and Adenosine affect the oxygen dependence of erythrocyte metabolism
Francesco Misiti
Cassino and Lazio Meridionale University
S16-3The role of macromolecular depletion on the adhesion of red blood cells with a reduced sialic acid content
Björn Neu 1, Huimin Teo 2, Zhengwen Zhang 2
1 Rhine-Waal University of Applied Sciences, 2 Nanyang Technological University
S16-4The Mizar®: a novel, fully-automated aggregometer
Lennart Kuck 1, Francesco A. Frappa 2, Michael J. Simmonds 1
1 Biorheology Research Laboratory, Menzies Health Institute Queensland, Australia, 2 Alcor Scientific Inc., Rhode Island, USA
S17: Microrheological responses of blood cells under normal and pathological conditions
Chairs: Alexei Muravyov, Nadia Antonova
S17-1Development of experimental microfluidic device and methodology for assessing microrheological properties of blood
Nadia Mladenova Antonova 1, Khristo Khristov 2, Anika Svilenova Alexandrova 3, Alexei Vasilievich Muravyov 4
1 Dept. Biomechanics, Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, 2 Institute of Physical Chemistry at the Bulgarian Academy of Sciences, Sofia, Bulgaria, 3 Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, 4 Yaroslavl State Pedagogical University Ushinskii, Yaroslavl, Russia
S17-2Comparative study of the microrheological properties of the blood in patients with type 2 diabetes mellitus, using viscosimetry and microfluidic flow analysis
Anika Svilenova Aleksandrova-Watanabe 1, Nadia Mladenova Antonova 1, Alexey Vasilievich Muravyov 2, Khristo Ivanov Khistov 3, Irena Vasileva Velcheva 4
1 Dept. of Biomechanics, Institute of Mechanics, Bulgarian Academy of Sciences, Sofia, Bulgaria, 2 Dept. of Medical and Biological Foundations of Sports, Yaroslavl State Pedagogical University named after K. D. Ushinsky, Yaroslavl, Russia, 3 Dept. of Interfaces and Colloids, Institute of Physical Chemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria, 4 Clinic of Nervous Diseases, Uni Hospital, Panagyurishte, Bulgaria
S17-3Microrheological responses of red blood cells (RBCs) to gasotransmitters in persons with different levels of oxygen supply to the body
Alexei Vasilievich Muravyov 1, Pavel Valentinovich Mikhailov 1, Irina Alexandrovna Tikhomirova 1, Roman Sergeevich Ostroumov 1, Victor Vasilievich Zinchuk 2
1 State pedagogical university, Yaroslavl, 2 State Medical University, Grodno, Belarus
S17-4Effect of gasotransmitters (NO and H2S) on hemorheology and blood clotting
Irina Alexandrovna Tikhomirova 1, Elena Petrovna Petrochenko 1, Yulia Viktorovna Malysheva 1, Alexei Vasiljevich Muravyov 1, Alexander Sergeevich Petrochenko 2
1 Yaroslavl State Pedagogical University, 2 Yaroslavl State Medical University
S17-5Interaction forces of pair interaction of RBCs and their relation to aggregation parameters under normal and pathological conditions
Alexander V. Priezzhev 1, Andrei E. Lugovtsov 1, Alexey N. Semenov 1, Larissa I. Dyachuk 2, Petr B. Ermolinskiy 1
1 Physics Department of Lomonosov Moscow State University, 2 Medical Research and Education Centre of Lomonosov Moscow State University
S17-6Microrheological responses of RBCs after age (density) separation
Petr Ermolinskiy 1 Andrei Lugovtsov 1, François Yaya 2,5, Lars Kaestner 2,3, Christian Wagner 2,4, Alexander Priezzhev 1
1 Physics Department, Lomonosov Moscow State University, 119991 Moscow, Russia, 2 Experimental Physics, Saarland University, 66123 Saarbrücken, Germany, 3 Theoretical Medicine and Biosciences, Saarland University, 66123 Saarbrücken, Germany, 4 Physics and Materials Science Research Unit, University of Luxembourg, L-1511 Luxembourg, Luxembourg, 5 Laboratoire Interdisciplinaire de Physique, UMR 5588 CNRS and University Grenoble–Alpes, 38058 Grenoble, France
16:40–18:10 Symposia S19–S20
S19: Microcirculation disturbances, blood microrheological properties and functional states of leukocytes
Chairs: Nadia Mladenova Antonova
S19-1Disturbances in skin temperature oscillations and blood rheological and electrical properties in patients with Diabetes mellitus type 2
Nadia Mladenova Antonova 1, Vasilka Krumova Paskova 2, Irena Vasileva Velcheva 3, Sergey Yurievich Podtaev 4
1 Dept. Biomechanics, Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, 2 Institute of Mechanics at the Bulgarian Academy of Sciences, Sofia, Bulgaria, 3 Uni Hospital, Panagyurishte, Bulgaria, 4 Institute of Continuous Media Mechanics, RAS, Perm, Russia
S19-2Functional states of PMN in pregnant women with hypertension assessed with chemiluminescent method - preliminary data
B. Bechev 1, M. Magrisso 2, S. Stoeff 1, Sv. Jovtchev 1, S. Miteva 1, S. Alexandrov 1, J. Ivanov 1, M. Pencheva 3, D. Koleva 4, I. Buteva 4, M. Vretenarska 5, N. Nikolova 6 and V. Iliev 6,7
1 Dept Medical Physics and Biophysics and 3Dept Biology of Medical University Sofia, Bulgaria, 2Omrad Electronics LTD, Beer Sheva, Israel, 4OGW/MHAT “Nadezhda” Sofia, 52nd MHAT Sofia, Nephrology Ward, 6MC Vitclinic, 7Military Medical Academy of Sofia
S19-3Participation of polymorphonuclear leukocytes in initiation and evolvement of pathologies induced by SARS-Cov-2 virus
B. Bechev 1, S. Stoeff 1 and K. Kavaldzhieva 2
1 Dept Medical Physics and Biophysics, 2 Dept Biology of Medical University Sofia, Bulgaria
S20: Nanomechanical and nanorheological assessments of various diseases
Chairs: Malgorzata Lekka, Joanna Zemla
S20-1Search for efficient diagnosis and therapy of resistant BRAF mutated melanoma using biophysical methods
Tomasz Kobiela 1, Anna Sobiepanek 1, Swamy Kasarla 1, Weronika Prorok 1, Tomasz Gambin 2
1 Warsaw University of Technology, Faculty of Chemistry, 2 Warsaw University of Technology, Faculty of Electronics and Information Technology
S20-2Rheological properties of biological materials
Joanna Zemla 1, Claude Verdier 2, Malgorzata Lekka 1
1 Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland, 2 Laboratoire Interdisciplinaire de Physique, Université Grenoble Alpes, CNRS, Grenoble, F-38000, France
S20-3Nanomechanical assessment of cancer cells and solid tumors as a mechanical biomarker
Andreas Stylianou 1,2
1 European University Cyprus, 2 University of Cyprus
16:40–18:30Free Communication (ePoster)
19:20–20:00ESCHM-ISCH-ISB Combined Business Online Meeting
20:10–22:00Symposium S21
S21: Shear stress and red cell rheology
Chairs: Edgar O’Rear, Ozlem Yalcin
S21-1Cell age sensitivity of red cells to mechanical stresses and calcium load
Lennart Kuck 1, Jason N. Peart 2, Oliver Todd 1, *Michael J. Simmonds 1
1 Biorheology Research Laboratory, Menzies Health Institute, Griffith University Gold Coast, Queensland, Australia, 2 School of Medical Science, Griffith University Gold Coast, Queensland, Australia
S21-2Senescence and red cell rheology
Edgar O’Rear 1, James Buerck 1, Phillip Coghill 2, Ahmed El Banayosy 3, Hendra Setiadi 3
1 University of Oklahoma, 2 VADovations, Inc., 3 INTEGRIS Baptist Medical Center
S21-3Asymmetrical erythrocyte morphology to detect sublethal damage
Nobuo Watanabe 1,2, Antony P. McNamee 3, Jarod T. Horibin 3,4, John F. Fraser 5, Masataka Inoue 2, Masaya Hakozaki 2, Fukuta Matsuzawa 2, Michael J. Simmonds 3
1 Biofluid Science and Engineering Laboratory, Dept. of Bio-Science and Engineering, College of Systems Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, 2 Biofluid Science and Engineering Laboratory, Systems Engineering and Science, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, 3 Biorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia, 4 Perth Blood Institute, West Perth, Perth, Australia, 5 Critical Care Research Group, University of Queensland & The Prince Charles Hospital, Brisbane, Australia
S21-4Effects of mechanical heart valves on circulating blood in patients with valvular heart diseases
Toru Maruyama 1, Michinari Hieda 1, Aya Sato 2, Takehiko Fujino 2
1 Kyushu University, 2 Institute of Rheological Function of Foods, Co. Ltd.
S21-5A structured mechanical risk sensitivity assessment system using red cell deformability and fragmentation parameters
Ozlem Yalcin 1,2, Elif Ugurel 2, Polat Goktas 1, Evrim Goksel 1,3, Neslihan Cilek 1,3, Dila Atar 1
1 Koç University, School of Medicine, Istanbul, Turkey, 2 Koç University, Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey, 3 Koç University, Graduate School of Biomedical Sciences and Engineering, Istanbul, Turkey
S21-6Measurements of erythrocyte deformation in shear and extensional flows
M Keith Sharp 1, Mohammad M Faghih 2
1 University of Louisville, 2 US Food and Drug Administration
S21-7In silico simulation of hemodynamics and blood cell mechanics inside human vasculature
Senol Piskin 1, Aya Ahmed Faeek Elgebaly 2
1 Department of Mechanical Engineering, College of Engineering, Istinye University, Istanbul, Turkey, 2 Department of Biomedical Engineering, Faculty of Electrical and Electronics Engineering, Yildiz Technical university, Istanbul, Turkey
20:30–22:00 Symposia S22–S23
S22: Microbiorheology from molecules to tissues
Chairs: Daisuke Mizuno, Kengo Nishi
S22-1Motion of molecular motors reflecting rheological properties in cells
Takayuki Ariga
Yamaguchi University
S22-2Glassy cytoplasm driven by non-thermal forces
Kenji Nishizawa 1,2, Daisuke Mizuno 3
1 IBDM, 2 CNRS, 3 Department of Physics, Kyushu University
S22-3Metabolism-Dependent Active Diffusion in Living Cells
Yujiro Sugino 1, Kenji Nishizawa 2, Daisuke Mizuno 1
1 Department of Physics, Kyushu University, 2 IBDM-CNRS
S22-4Microrheology of a concentrated emulsion as a model cytoplasm
Shono Inokuchi, Ryosuke Matsuoka, Daisuke Mizuno
Kyushu University
S22-5Non-equilibrium fluctuations in cells report on driving forces and organelle mechanics
Kengo Nishi 1,2, Sufi Raja 1, An Pham 1, Fred C MacKintosh 3, Christoph F Schmidt 1
1 Duke University, 2 UNC Chapel Hill, 3 Rice University
S23: Clinical studies using various assays for platelets and hemostasis
Chairs: Paul Gurbel, Young-Hoon Jeong
S23-1The Global Thrombosis Test
*Diana Adrienne Gorog
University of Hertfordshire & Imperial College, London
S23-2Thromboelastography: Viscoelastic properties of clot formation and their clinical impact in ASCVD patients
Young-Hoon Jeong
Gyeongsang National University Changwon Hospital
S23-3Clinical Trial with Microfluidic Platelet Function Assays(Anysis-200): Comparison with Turbidity-based Drug Response Assay(Verify-NOW
Byoung Kwon Lee 1, Miney Cho 1, Sehyun Shin 2
1 Cardiology, Department of Internal Medicine, Gangnam severance Hospital, Yonsei University, Seoul, Korea, 2 Department of Mechanical Engineering, Korea University, Seoul, Korea
S23-4T-TAS 01: A novel flow-based system for hemostasis monitoring
Jeffrey Dahlen
Fujimori Kogyo Co., Ltd.
July 7, 2021
9:00–10:30 Symposia S24–S26
S24: Cell mechanics and cell mechanobiology
Chairs: Toshiro Ohashi, Taiji Adachi, Susumu Kudo
S24-1Identification of leader cells in cell migration by filopodia using computer vision
Baasansuren Otgon 1, Ganbat Danaa 2, Toshiro Ohashi 3
1 Graduate School of Engineering, Hokkaido University, Japan, 2 Open Education Center, Mongolian University of Science and Technology, Mongolia, 3 Faculty of Engineering, Hokkaido University, Japan
S24-2Intracellular tension of osteoblast in collagen gel elicits osteocyte alignment under uniaxially-fixed boundary condition
*Jeonghyun Kim 1, Keiichi Ishikawa 2, Junko Sunaga 2, Taiji Adachi 2
1 Nagoya University, 2 Kyoto University
S24-3Emulating endothelial dysfunction by mimicking the microenvironment of early atherosclerotic lesions within a microfluidic chip
Bomi Gweon 1, Yujin Shin 2
1 Sejong University, 2 Hanyang University
S24-4Enhancement and stabilization of sprouting angiogenesis by curvature-oriented behaviors of mesenchymal stem cells
Takanori Sano 1, Jun-Ichi Kawabe 2, Yukiko T. Matsunaga 1
1 Institute of Industrial Science, The University of Tokyo, 2 Asahikawa Medical University
S24-5Mechanism driving hydrostatic pressure-induced endothelial tube formation
Daisuke Yoshino
Tokyo University of Agriculture and Technology
S25: Microparticle and cell behavior in confined fluid flows - 1
Chairs: Masako Sugihara-Seki, Naoki Takeishi, Ryoko Otomo
S25-1Numerical analysis of the inertial migration of red blood cells in a channel
Naoki Takeishi 1, Hiroshi Yamashita 1,2, Naoto Yokoyama 3, Seki Masako 1,2, Shigeo Wada 1
1 Osaka University, 2 Kansai University, 3 Tokyo Denki University
S25-2Droplet breakup limits in simple shear flows
Mohamed Shoieb Abdelgawad, Marco Edoardo Rosti
Okinawa Institute of Science and Technology
S25-3Swelling and hemolytic behavior of human red blood cells in hypotonic fluid
Ryoko Otomo, Ryuta Minami, Kiyoshi Bando
Kansai University
S25-4Spectral change of stress-responsive fluorescent molecule caused by the hydrodynamic stress field of microchannel flow
Reiko Kuriyama 1, Waka Yamamoto 1, Hidetsugu Kitakado 2, Shohei Saito 2, Kazuya Tatsumi 1, Kazuyoshi Nakabe 1
1 Department of Mechanical Engineering and Science, Kyoto University, 2 Graduate School of Science, Kyoto University
S25-5Segregation in shear-thickening materials
Alessandro Monti, Marco Edoardo Rosti
Okinawa Institute of Science and Technology (OIST)
S26: Contributing role of erythrocytes for platelet adhesion and thrombus formation
Chairs: Shinya Goto
S26-1Important physical regulatory roles of erythrocytes on platelet adhesion under blood flow conditions
Noriko Tamura 1,2, Kazuya Shimizu 3, Seiji Shiozaki 2, Kazuyasu Sugiyama 4, Masamitsu Nakayama 2, Shinichi Goto 2, Shu Takagi 3, Shinya Goto 2
1 Department of Health and Nutrition, Niigata University of Health and Welfare, 2 Department of Medicine (Cardiology), Research Center for Metabolic Disease, Tokai University School of Medicine and Tokai University Graduate School of Medicine, 3 Graduate School of Engineering, The University of Tokyo, 4 Department of Mechanical Science and Bioengineering, Osaka University School of Engineering Science
S26-2Physical interactions between platelets and erythrocytes play an important role for initial platelet adhesion mediated by the interaction of glycoprotein 1b with von Willebrand factor.
Shinichi Goto 1,2,3, Noriko Tamura 4, Kazuya Shimizu 5, Masamitsu Nakayama 3, Shu Takagi 5, Shinya Goto 3
1 Brigham and Women’s Hospital, Harvard Medical School, 2 Keio University School of Medicine, 3 Tokai University School of Medicine, 4 Niigata University of Health and Welfare, 5 The University of Tokyo
S26-3Water-ethanol separation with tip charged carbon nanotubes
Yuui Ono, Eiji Yamamoto, Kenji Yasuoka
Keio University
S26-4[Withdrawn]
10:40–12:10 Symposia S27–S28
S27: Microparticle and cell behavior in confined fluid flows - 2
Chairs: Masako Sugihara-Seki, Naoki Takeishi, Ryoko Otomo
S27-1Inertial focusing of red blood cells suspended in blood plasma flowing through square tubes
Masako Sugihara-Seki 1,2, Saori Tanaka 1
1 Kansai University, 2 Osaka University
S27-2Role of fluid dynamics in optical trapping
Tetsuro Tsuji
Kyoto University
S27-3Deformable particle suspensions
Marco Edoardo Rosti
Okinawa Institute of Science and Technology
S27-4On-chip manipulation for revealing novel aspects of red blood cell mechanics
Hiroaki Ito
Chiba University
S27-5Measurement of near-wall microparticles motion under the influence of radiation pressure of evanescent field
Miyu Inoue, Reiko Kuriyama, Kazuya Tatsumi, Kazuyoshi Nakabe
Kyoto University
S28: Joint symposium with commons for medicine and engineering japan: Application of high performance computer for biorheology
Chairs: Shinya Goto, Kazuo Tanishita
S28-1Protein disintegration as a possible mode of protein dissociation between GP1b𝛼 and VWF in blood flow condition: Insights from steered molecular dynamic simulation.
Shinichi Goto 1,2,3, Masamitsu Nakayama 2, Shu Takagi 4, Shinya Goto 2
1 Brigham and Women’s Hospital, Harvard Medical School, 2 Tokai University School of Medicine, 3 Keio University School of Medicine, 4 Graduate School of Engineering, The University of Tokyo
S28-2Salt bridge formation between A1 domain of von Willebrand Factor and Platelet Glycoprotein (GP) Ib𝛼 by molecular dynamics simulations
Masamitsu Nakayama, Shinichi Goto, Shinya Goto
Tokai University School of Medicine
S28-3Finite element analysis of blood clots through visco-hyperelastic constitutive theories
Koichiro Tashiro 1,2, Yasuhiro Shobayashi 2, Iku Ota 1, Atsushi Hotta 1
1 Department of Mechanical Engineering, Keio University, 2 Biomedical Solutions Inc.
S28-4Newly developed drug-eluting stent (DES) system for cardiovascular diseases: Hybrid nano-coating technology
Terumitsu Hasebe 1,2, Shunto Maegawa 1,3, Kenta Bito 1,3, Yutaka Okamoto 3, Shunsuke Kamei 1, Shota Yamamoto 1,3, Kosuke Tomita 1, Satoshi Suda 1, Kazunobu Hashida 1, Tomohiro Matsumoto 1, Yoko Usami 4,1, Yasutaka Baba 4,1, Yutaka Imai 1, Atsushi Hotta 3
1 Tokai University Hachioji Hospital, Tokai University School of Medicine, 2 Keio University Hospital Clinical & Translational Research Center, 3 Keio University Faculty of Science and Technology, 4 Saitama Medical University International Medical Center
12:10–13:10 Plenary Lecture in Tribute to Prof. Akira Kamiya
Chair: Joji Ando
PL7Emerging roles of membrane lipids and mitochondria in endothelial cell mechanosensing
Kimiko Yamamoto
The University of Tokyo
14:00–15:00 Closing Plenary Lecture for ISB
Chair: Peter Butler
PL8The mechanotransduction of cancer and blood cells exposed to circulatory levels of fluid shear stress
Michael R. King
Vanderbilt University
15:00–15:50Closing Ceremony
On-demand Program
Free Communication (Video presentation)
O2: Hemorheology in health and disease-1
O2-1Effects of L-arginine on blood fluidity impaired after high-intensity exercise: An in vitro evaluation
Haruchi Namba 1, Tatsushi Kimura 2, Hironobu Hamada 1, Kiyokazu Sekikawa 1, Hatsumi Ishio-Ueoka 1, Teruki Kajiwara 1, Yoshinobu M Sato 1, Fumiya Aizawa 1, Takamasa Yoshida 1, Naoto Kanda 1, Aoi Takagi 1
1 Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan, 2 Faculty of Early Childhood Education and Care, Ohkagakuen University, Aichi, Japan
O2-2Hematological and hemorheological changes in a model of atherosclerotic disease in rabbits
Bence Tanczos 1, Viktoria Somogyi 1, Mariann Bombicz 2, Bela Juhasz 2, Norbert Nemeth 1, Adam Deak 1
1 Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2 Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Hungary
O2-3Examination of the hemorheological changes in a rat model of polycystic ovary syndrome
Barbara Barath 1, Adam Varga 1, Adam Attila Matrai 1, Pathan Afrin Javed 1, Krisztina Deak-Pocsai 2, Norbert Nemeth 1, Adam Deak 1
1 Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2 Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
O2-4The hazard of PLGA nanoparticles on intima hyperplasia of vascular restenosis in ApoE-/- mice.
Tieying Yin 1, Wen Shi 1, Atik Rohmana Maftuhatul Fuad, Yanhong Li 1, Yang Wang 1, Junyang Huang 1, Ruolin Du 1, Guixue Wang 1, Yazhou Wang 2
1 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, 2 School of medicine, Chongqing University, Chongqing, 400030, China
O3: Hemorheology in health and diseases-2
O3-1Is leptin an significant regulator of erythrocyte rheology?
Jean-Frederic Brun 1, Emmanuelle Varlet-Marie 2, Laurent Vachoud 3, Bénédicte Marion 2, Céline Roques 2, Eric Raynaud de Mauverger 1, Jacques Mercier 1
1 PhyMedExp, CNRS UMR 9214, INSERM U1046, University of Montpellier, and Department of Clinical Physiology, 2 Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université de Montpellier, Ecole Nationale Supé rieure de Chimie de Montpellier, France, 3 Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université de Montpellier, France
O3-2Which sub-compartments of fat mass and fat-free mass are related to blood viscosity factors?
Jean-Frederic Brun 1, Emmanuelle Varlet-Marie 2, Laurent Vachoud 3, Bénédicte Marion 2, Céline Roques 2, Eric Raynaud de Mauverger 1, Jacques Mercier 1
1 PhyMedExp, CNRS UMR 9214, INSERM U1046, University of Montpellier, and Department of Clinical Physiology, 2 Institut des Biomolécules Max Mousseron (IBMM) UMR CNRS 5247, Université de Montpellier, Ecole Nationale Supérieure de Chimie de Montpellier, France, 3 Laboratoire de Biophysique & Bio-Analyses, Faculté de Pharmacie, Université de Montpellier, France
O3-3A link between storage-related sequence of nanoscale changes in RBC membranes and their biochemical and morphological properties
Ewa Szczesny-Malysiak 1, Magdalena Kaczmarska 1, Katarzyna Bulat 1, Anna Zimna 1,2, Fatih Celal Alcicek 1, Jakub Dybas 1, Katarzyna Maria Marzec 1
1 Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, Krakow, Poland, 2 Faculty of Pharmacy, Jagiellonian University Medical College, Krakow, Poland
O3-4Investigation of effect of measurement time for transmitted light through blood on relationship between erythrocytes’ sedimentation velocity and aggregation parameters
Makoto Higuchi 1,2, Nobuo Watanabe 1
1 Biofluid Science and Engineering Laboratory, Functional Control Systems, Graduate School of Engineering and Science, Shibaura Institute of Technology, Saitama, Japan, 2 Ogino Memorial Laboratory, Nihon Kohden Corporation, Saitama, Japan
O4: Red cell deformability in humans and mammalians
O4-13-D analysis of the deformation of RBCs in a doublet while tuning the interaction
Mehrnaz Babaki 1,2, Pavlik Lettinga 1,2
1 Biomacromolecular Systems and Processes (IBI-4), Forschungszentrum Jülich GmbH, Jülich, Germany, 2 Laboratory for Soft Matter and Biophysics, KU Leuven, Leuven, Belgium
O4-2Osmotic gradient ektacytometric parameters in human and seven mammalian species
Adam Varga, Barbara Barath, Adam Attila Matrai, Viktoria Somogyi, Adam Deak, Norbert Nemeth
Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
O4-3Effect of heat stress on macro- and micro-rheological parameters in an experimental model
Barbara Barath 1, Xenia Ozsvath 2, Viktoria Somogyi 1, Adam Varga 1, Laszlo Babinszky 3, Norbert Nemeth 1, Adam Deak 1
1 Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2 Department of Animal Husbandry, Institute of Animal Health, Biotechnology and Nature, Faculty of Agricultural and Food Sciences and Environmental Management, University of Debrecen, Debrecen, Hungary, 3 Non-independent Division of Animal Nutrition, Faculty of Agricultural and Food Sciences and Environmental Sciences, University of Debrecen, Debrecen, Hungary
O4-4In vitro effects of heat-treatment on red blood cell micro-rheology in human and various vertebrate species
Adam Attila Matrai 1, Gabor Varga 1, Bence Tanczos 1, Barbara Barath 1, Adam Varga 1, Laszlo Horvath 2, Zsuzsanna Bereczky 3, Adam Deak 1, Norbert Nemeth 1
1 Department of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, 2 Department of Pharmaceutical Surveillance and Economics, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary, 3 Division of Clinical Laboratory Science, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
O4-5Activation of Protein kinase A cascade increases deformability of sickle red blood cells
Evrim Goksel 1,2, Philippe Connes 4,5,6, Camille Boisson 4,5,7, Céline Renoux 4,5,7, Alexandra Gauthier 4,5,8, Romain Fort 4,5,9, Elie Nader 4,5, Solène Poutrel 4,5,9, Ozlem Yalcin 1,2,3
1 Research Center for Translational Medicine (KUTTAM), Koç University, Istanbul, Turkey, 2 Department of Physiology, Koc University School of Medicine, Istanbul, Turkey, 3 School of Medicine, Koç University, Istanbul, Turkey, 4 Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Equipe “Biologie Vasculaire et du Globule Rouge”, UCBL1, Villeurbanne, France, 5 Laboratoire d’Excellence (Labex) GR-Ex, Paris, France, , 6 Institut Universitaire de France, Paris, France, 7 Laboratoire de Biochimie et de Biologie Moléculaire, UF de Biochimie des Pathologies Érythrocytaires, Centre de Biologie et de Pathologie Est, Hospices Civils de Lyon, 69500 Bron, France, 8 Institut d’Hématologie et d’Oncologie Pédiatrique, Hospices Civils de Lyon, 69008 Lyon, France, 9 Département de Médecine Interne, Hôpital Edouard Herriot, Hospices Civils de Lyon, 69008 Lyon, France.
Free Communication (ePoster)
P-1Impaired deformability and association with density distribution of erythrocytes in patients with type 2 diabetes mellitus under treatment
Toru Maruyama 1, Michinari Hieda 1, Takeshi Arita 2, Taku Yokoyama 1, Mitsuhiro Fukata 1, Takehiko Fujino 3, Koichi Akashi 1
1 Kyushu University, 2 Fukuoka Wajiro Hospital, 3 BOOCS Clinic
P-2Prognostic significance of red cell distribution width in hospitalized old patients with bacterial infection
Toru Maruyama 1, Keitaro Nakashima 2, Eiichi Ohgami 2, Kazuhiko Katoh 2, Souichi Yoshitomi 2, Mine Harada 2
1 Kyushu University, 2 Karatsu Higashimatsuura Medical Center
P-3Results of blood research relating torheology, morphology and biochemistry of blood in a man living 50 days in extremely low temperatures
Aneta Teleglow 1, Anna Marchewka 1, Maria Fornal 2, Zbigniew Dąbrowski 1, Jakub Marchewka 1, Bartłomiej Ptaszek 1, Mateusz Mardyła 1, Dariusz Mucha 1, Łukasz Tota 1, Marcin Maciejczyk 1
1 University of Physical Education, Krakow, Poland, 2 Jagiellonian University Medical College, Krakow, Poland
P-4Activation of K+ ATP channels is involved additively in NO-induced vasodilation
Noriko Iida
ex-Department of Neurophysiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
P-5Stiffening of the human keratinocytes in response to the cyclic temperature changes
Yan Nie 1,2, Weiwei Wang 1, Xun Xu 1, Nan Ma 1,3, Andreas Lendlein 1,2,3
1 Institute of Active Polymers and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Hereon, 2 Institute for Biochemistry and Biology, University of Potsdam, 3 Institute of Chemistry and Biochemistry, Free University of Berlin
P-6Extensional rheology of semidilute entangled solutions of polyelectrolytes in a cross-slot microchannel
Arisa Yokokoji 1, Tadashi Inoue 1, Atsushi Matsumoto 2, Simon J Haward 3, Amy Q Shen 3
1 Department of Macromolecular Science, Graduate school of Science, Osaka University, Toyonaka, Osaka 560-0043, Japan, 2 Department of Applied Chemistry and Biotechnology, University of Fukui, Fukui-shi, Fukui 910-8507, Japan, 3 Micro/Bio/Nanofluidics Unit, Okinawa Institute of Science and Technology Graduate University (OIST), Onna, Okinawa 904-0495, Japan
P-7Entrapment dynamics of micro-particles in a Pulmonary Capillary Network (PCN) microfluidic device
Merav Belenkovich, Josué Sznitman, Netanel Korin
Faculty of Biomedical Engineering, Technion- Israel Institute of Technology
P-8Time-series snapshots of the entire circumferential wall of arteries under pulsatile pressure condition captured by grating-based phase-contrast CT
Takeshi Matsumoto 1, Hiroyuki Tachibana 2, Masato Hoshino 3
1 Tokushima University, 2 Kawasaki University of Medical Welfare, 3 SPring-8
P-9Hemorheology and blood coagulation in COVID-19 patients
Irina Alexandrovna Tikhomirova 1, Mihail Mihajlovich Ryabov 2
1 Yaroslavl State Pedagogical University, 2 Yaroslavl State Medical University
P-10Extended fibrinolysis times in vitro of clots containing erythrocyte microparticles formed by supraphysiologic shear stress
Kylie Foster 1,2, James Buerck 1, Edgar O’Rear 1
1 University of Oklahoma, 2 VADovations Inc.
P-11[Withdrawn]
P-12[Withdrawn]
P-13[Withdrawn]
P-14Change in oxygen transport by erythrocytes treated with TiO2 nanoparticles and functionalized carbon nanotubes
Magdalena Peter 1, Jarosław Kiecana 2, Aleksander Siniarski 2,3, Grzegorz Gajos 2,3, Józef Korecki 4, Kvetoslava Burda 1
1 UST (University of Science and Technology), Cracow, Poland, 2 The John Paul II Hospital, Cracow, Poland, 3 Jagiellonian University, Medical College, Cracow, Poland, 4 Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Cracow, Poland.
P-15[Withdrawn]
P-16Hemodynamic characteristics of fully polymer bioresorbable scaffolds of rats in different ages
Tieying Yin 1, Wen Shi 1, Atik Rohmana Maftuhatul Fuad 1, Yanhong Li 1, Yang Wang 1, Junyang Huang 1, Ruolin Du 1, Guixue Wang 1, Yazhou Wang 2
1 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, 2 School of medicine, Chongqing University, Chongqing, 400030, China