Affiliations: Humboldt-Universität, Bereich Medizin, Inst. f. med. Physik & Biophysik, Abt. Haemorheologie & Haemodynamik, DDR-1040 Berlin, German Democratic Republic
Note: [1] Presented at the Vth International Congress of Biorheology, Baden-Baden, FRG, 1983.
Abstract: On the basis of a recently developed biophysical model of cell-cell interaction, including electrostatic, electrodynamic, steric and bonding/bridging interaction energies the influence of different fixed charge (dissociated groups of the glycocalyx) density distributions in red blood cell (REC) glycocalyces on the total free interaction energy was investigated. An analytical equation of electrostatic free energy on the basis of the linear Poisson-Boltzmann approach taking into account arbitrary distributions of fixed glycocalyx charges was obtained and corresponding free electrostatic energies of three example distributions were calculated. The electrodynamic, steric and bonding/bridging energies were computed as usual. It was shown that the free energy as a function of interaction distances strongly depends on the charge distribution and, correspondingly, the “weight” of this energy term in the total free interaction energy balance equation. Generally, it can be stated that as more charges are assumed to be fixed in the outer layer of REC glycocalyx as more important becomes the electrostatic energy in contrast to the remaining three terms.
Keywords: red blood cells, glycocalyx, surface structure, total interaction energy, aggregation
DOI: 10.3233/BIR-1984-21407
Journal: Biorheology, vol. 21, no. 4, pp. 477-492, 1984
