Usefulness of whole blood viscosity estimated by de Simeone’s formula to predict left ventricular thrombus formation within one year following acute anterior myocardial infarction

Article type: Research Article

Authors: Çırakoğlu, Ömer Faruk^a; | Aslan, Ahmet Oguz^b | Yilmaz, Ahmet Seyda^c | Kul, Selim^a | Dursun, İhsan^a

Affiliations: [a] Department of Cardiology, Trabzon Ahi Evren Training and Research Hospital, University of Health Science, Trabzon, Turkey | [b] Department of Cardiology, Akçaabat Haçkalı Baba State Hospital, Trabzon, Turkey | [c] Department of Cardiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, Turkey

Correspondence: [*] Corresponding author: Ömer Faruk Çırakoğlu, MD, Saglik Bilimleri Universitesi, Ahi Evren Kalp ve Damar Cerrahisi EAH, Kardiyoloji Anabilim Dali, Soguksu Vatan St. No: 9, 61040 Trabzon, Turkey. Tel.: +90 4622310464; Fax: +90 4622310483; E-mail: [email protected]

Abstract: BACKGROUND:Despite improvements in treatment of ST-segment myocardial infarction (STEMI), thrombus formation in the left ventricle is still a concerning complication that may lead to systemic thromboembolism and stroke. OBJECTIVES:To evaluate the predictive value of estimated whole blood viscosity (WBV) for left ventricular thrombus development in patients surviving an acute anterior myocardial infarction (AAMI). MATERIALS \& METHODS:Seven hundred eighty AAMI patients who were treated percutaneously were enrolled consecutively. Serial echocardiographic examinations were performed within 24h of admission, before hospital discharge, and at 1, 3, 6 and 12 months following hospital discharge. WBV was calculated according to de Simones formula. RESULTS:One hundred patients (12.8%) developed thrombus formation within one year following AAMI. Patients with left ventricular thrombus (LVT) had significantly higher WBV values. Supramedian values of WBV at both low (0.5 sec−1) and high (208 sec−1) shear rates were found to be an independent predictor of LVT development. CONCLUSION:As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction.

Keywords: Blood viscosity, shear stress, left ventricular thrombus, myocardial infarction

DOI: 10.3233/BIR-200240

Journal: Biorheology, vol. 57, no. 1, pp. 37-51, 2020