Resonance-thrombography, theoretical and practical elements

Issue title: Perspectives in Biorheology. Festschrift for A.L. Copley

Guest editors: Alexander Silberberg

Article type: Research Article

Authors: Hartert, Hellmut H.

Affiliations: Medizinische Klinik I, Stadtkrankenhaus Kaiserslautern, 6750 Kaiserslautern, West Germany FRG

Note: [] Invited by: Editor A. Silberberg

Abstract: Resonance-Thrombography is a successor method of Thrombelastography. Clotting in this technique starts in blood or plasma in a flowing state and is after appearance of the first fibrin strands followed by measuring continuously the elasticity of the growing clot. In the measuring procedure the clot is subject to permanent strain by an orbital movement. Its oscillation causes a stretching procedure of fibrin molecules and gives an assay of clot elasticity by recording a differentiating resonance effect. The Resonance-Thrombogram (RTG) delivers distinguishable and characteristic types of graphs for qualitative and quantitative differences in fibrin production. Separated from the latter quantitative and qualitative changes in platelet activity are evident. Examples for diagnostic screening are dysfibrinogenemia, disseminated intravascular clotting, thrombocytopathy and -penia. Another field is the panorama of thrombin-like substances as Ancrod and Thrombin-Coagulase, the surveying of which in the RTG will yield more revealing results in clinical situations than the corresponding one-stage tests.

Keywords: Resonance-Thrombography, clot structure, dysfibrinogenemia, platelet shape-change, thrombopathy, thrombin-like substances

DOI: 10.3233/BIR-1981-183-631

Journal: Biorheology, vol. 18, no. 3-6, pp. 693-701, 1981