Relationship between arterial blood pressure and blood viscosity in spontaneously hypertensive rats treated with pentoxifylline

Article type: Research Article

Authors: Plotnikov, Mark B.^{a; *} | Aliev, Oleg I.^a | Nosarev, Alexey V.^b | Shamanaev, Alexander Y.^a | Sidekhmenova, Anastasia V.^a | Anfinogenova, Yana^{c; d} | Anishchenko, Anna M.^a | Pushkina, Ekaterina V.^b

Affiliations: [a] E.D. Goldberg Institute of Pharmacology and Regenerative Medicine, Russian Academy of Sciences, Tomsk, Russia | [b] Siberian State Medical University, Tomsk, Russia | [c] Federal State Budgetary Scientific Institution “Research Institute for Cardiology”, Tomsk, Russia | [d] RASA Center in Tomsk, Tomsk Polytechnic University, Tomsk, Russia

Correspondence: [*] Address for correspondence: Mark B. Plotnikov, E.D. Goldberg Institute of Pharmacology and Regenerative Medicine, Russian Academy of Sciences, Tomsk, Russia. Tel.: +7-(3822)-41-82-73-83; Fax: +7-(3822)-41-42-35; E-mail: [email protected].

Abstract: Background:Systemic arterial pressure (AP) depends on two physiological variables: cardiac output (CO) and total peripheral resistance (TPR). The latter depends on vascular hindrance and blood viscosity (BV). However, the relative contributions of the vascular and rheological factors to TPR remain unclear. Objective:The aim of our work was to study the haemodynamic and haemorheologic effects of a treatment course with pentoxifylline (PTX) in SHRs in an effort to assess the impact of the rheological factor on TPR and AP. Methods:The effects of the treatment course with PTX (100 mg/kg/day p.o. for six weeks) on BV, plasma viscosity, haematocrit, erythrocyte aggregation and deformability, mean AP (MAP), stroke volume (SV), CO, and TPR were studied in SHRs and in control Wistar Kyoto (WKY) rats. Results:PTX-treated SHRs had a lower BV, lower erythrocyte aggregation, and higher erythrocyte deformability index compared with the controls. The TPR level was higher by 43% compared with that in WKY rats and did not differ from the values obtained from control SHRs. In SHRs, moderate and strong positive correlations were found between BV and MAP and between BV and TPR. PTX-treated SHRs did not have any significant correlations between the above mentioned parameters. Conclusions:Treatment with PTX attenuated whole blood viscosity, but did not affect the AP and hemodynamic parameters in the experimental SHRs compared with the control SHRs. The magnitude of the rheologic effects of PTX was insufficient to cause appreciable decreases in TPR and AP.

Keywords: Pentoxifylline, SHR, arterial blood pressure, total peripheral resistance, blood viscosity, aortic ring tone

DOI: 10.3233/BIR-15100

Journal: Biorheology, vol. 53, no. 2, pp. 93-107, 2016