Affiliations: Graduate Institute of Medical Biotechnology &
Department of Medical Biotechnology and Laboratory Science, Chang Gung
University, Kwei-san, Tao-yuan, Taiwan | Department of Clinical Pathology, Chang Gung Memorial
Hospital, Kwei-san, Tao-yuan, Taiwan | Graduate Institute of Clinical Medical Sciences,
College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan
Note: [] Address for correspondence: Dr. Hung-yao Ho, Graduate Institute
of Medical Biotechnology, Chang Gung University, 259, Wen-Hwa 1st road,
Kwei-san, Tao-yuan, Taiwan. Tel./Fax: +886 3 2118449; E-mail:
[email protected]
Abstract: Oxidative stress has been associated with degenerative diseases such
as cardiovascular and neurodegenerative diseases. Acute myocardial infarction
(AMI) is the major cause of death among cardiovascular diseases. Inflammation,
a major risk factor of AMI, is associated with leukocytic activation, secretion
of myeloperoxidase (MPO) and subsequent oxidant generation. It has been
hypothesized that oxidative stress is a risk factor for AMI. To test this
hypothesis, we studied profiles of oxidative damage and antioxidants in
patients with AMI. The levels of MPO, 8-OHdG, and 3-Cl-Tyr were higher in blood
specimens from AMI patients than in those of controls. Antioxidant levels, such
as vitamin E and glutathione peroxidase, were significantly lower in these
patients. The GSH/GSSG ratio, indicative of redox status, was also lower in AMI
patients. Such findings suggest that these AMI patients experience increased
oxidative stress. Moreover, markers in combination are better for evaluating
antioxidant status and monitoring cardiac events than the same markers used
separately.
