Affiliations: School of Life Sciences, Devi Ahilya University,
Indore, M.P., India
Note: [] Address for correspondence: Hamendra Singh Parmar,
School of Life Sciences, Devi Ahilya University, Takshashila Campus,
Khandwa Road Complex, Indore, M.P., 452017, India.
Tel.: +91 731 2477166; Fax: +91 731 2360026;
E-mail: [email protected]
Abstract: An investigation on the effects of four different concentrations of
peel extract from Citrus sinensis (CS) or Punica granatum (PG) in male mice
revealed the maximum glucose lowering and antiperoxidative activities at 25
mg/kg of CS and 200 mg/kg of PG. In a separate experiment their potential was
evaluated with respect to the regulation of alloxan induced diabetes mellitus.
While a single dose of alloxan (120 mg/kg) increased the serum levels of
glucose and α-amylase activity, rate of water consumption and lipid
peroxidation (LPO) in hepatic, cardiac and renal tissues with a parallel
decrease in serum insulin level, administration of 25 mg/kg of CS or 200 mg/kg
of PG was found to normalize all the adverse changes induced by alloxan,
revealing the antidiabetic and anti peroxidative potential of test fruit peel
extracts. Subsequent phytochemical analysis indicated that the high content of
total polyphenols in the test peels might be related to the antidiabetic and
antiperoxidative effects of the test peels.
