Affiliations: Laboratory of Toxicology, College of Veterinary
Medicine, Seoul National University, Seoul 151-742, Korea | Institute of Animal Medicine, College of Veterinary
Medicine, Kyeongsang National University, Chinju 600-701, Korea | Division of Wood Chemistry & Microbiology,
Korea Forest Research Institute, Seoul 130-712, Korea
Note: [] Corresponding authors: Don-Ha Choi, Ph.D., Division of Wood
Chemistry and Microbiology, Korea Forest Research Institute, 207
Cheongnyangni-Dong, Dongdaemun-Gu, Seoul 130-712, Korea. E-mail:
[email protected]. Or Myung-Haing Cho, Ph.D., Laboratory of Toxicology, College
of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea.
E-mail: [email protected]
Abstract: Previously we reported that cadalene extracted from Zelkova
serrata inhibited lung tumorigenesis in mice. However, the precise mechanism
has not yet investigated. Here, we examined the effects of cadalene on signal
pathways important for apoptosis, cell cycle, and protein translation in lung
cancer cells. Our results showed that cadalene suppressed the expression of Akt
and its phosphor-forms through controlling PI3K and PTEN. Cadalene also induced
apoptosis through facilitating pro-apoptotic protein expression. In addition,
cadalene caused cell cycle arrest and decreased mTOR-mediated protein
translation. Taken together, cadalene may be developed as a lung cancer
therapeutic agent in the future.
Keywords: Cadalene, lung cancer, apoptosis, cell cycle, protein translation
Journal: BioFactors, vol. 29, no. 2-3, pp. 67-75, 2007
