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Issue title: Food Factors
Article type: Research Article
Authors: Lee, Ki Won | Lee, Hyong Joo
Affiliations: Department of Food Science and Technology, School of Agricultural Biotechnology, and Center for Agricultural Biomaterials, Seoul National University, Seoul 151-742, Republic of Korea
Note: [] Address for correspondence: Hyong Joo Lee, PhD, Department of Food Science and Technology, Shillim-dong, Gwanak-gu, Seoul 151-742, Republic of Korea. Tel.: +82 2 880 4853; Fax: +82 2 873 5095; E-mail: [email protected]
Abstract: Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative diseases. The ROS-induced development of cancer involves malignant transformation due to altered gene expression through epigenetic mechanisms as well as DNA mutations. Considerable attention has been focused on identifying naturally occurring antioxidative phenolic phytochemicals that are able to decrease ROS levels, but the efficacies of antioxidant therapies have been equivocal at best. Several studies have shown that some antioxidants exhibit prooxidant activity under certain conditions and potential carcinogenicity under others, and that dietary supplementation with large amounts of a single antioxidant may be deleterious to human health. This article reviews the intracellular signaling pathways that respond to oxidative stress and how they are modulated by naturally occurring polyphenols. The possible toxicity and carcinogenicity of polyphenols is also discussed.
Keywords: Polyphenols, reactive oxygen species, antioxidant, prooxidant, tumor promotion, signal transduction
Journal: BioFactors, vol. 26, no. 2, pp. 105-121, 2006
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