Evaluation of chemopreventive action of Ginsenoside Rp1

Article type: Research Article

Authors: Kumar, Ashok | Kumar, Madhu | Panwar, Meenakshi | Samarth, Ravindra M. | Park, Tae Yoon | Park, Myung Hwan | Kimura, Hiroshi

Affiliations: Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302004, India | Ambo Institute, 467-17 Dogok-dong, Gangnam-ku, Seoul 135-535, Korea | Department of Experimental Radiology, Shiga University of Medical Science, Shiga 520-2192, Otsu, Japan

Note: [] Corresponding author. E-mail: [email protected]

Abstract: We evaluated the chemopreventive properties of Ginsenoside Rp1 on 7,12-Dimethyl benz (a) anthracene (DMBA) skin papillomagenesis in Swiss albino mice. A significant reduction in values of tumor incidence, tumor burden, and cumulative number of papilloma was observed in mice treated orally with Ginsenoside Rp1 continuously at pre-, peri- and post-initiational stages of papillomagenesis as compared to the control group. Chemopreventive potential of Ginsenoside Rp1 was also observed on the skin metabolizing enzymes in Swiss albino mice. Ginsenoside Rp1 produced a significant elevation in the skin microsomal cytochrome p-450 and cytochrome b5, glutathione S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GPX), glutathione reductase (GR), DT-diaphorase, superoxide dismutase (SOD) and catalase levels in the group of mice treated with Ginsenoside Rp1 for seven consecutive days. However, there was significant decrease in lipid peroxidation (LPO) level in Ginsenoside Rp1 treated group.

Keywords: Chemoprevention, skin papilloma, Ginsenoside Rp1, carcinogen metabolizing enzymes, Swiss albino mice

Journal: BioFactors, vol. 26, no. 1, pp. 29-43, 2006