Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Murakami, Toshiyuki | Miyakoshi, Masazumi | Araho, Daisuke | Mizutani, Kenji | Kambara, Toshimitsu | Ikeda, Takao | Chou, Wen-Hua | Inukai, Mihoko | Takenaka, Asako | Igarashi, Kiharu

Affiliations: Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan | South China Institute of Botany, Academia Sinica, Leyiji, Guangzhou 510650, P.R. China | Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-machi, Tsuruoka-shi, Yamagata 997-8555, Japan

Note: [] Corresponding author. Tel.: +81 847 52 5501; Fax: +81 847 52 5901; E-mail: [email protected]

Abstract: Hepatoprotective effect of the leaves and stems of Ampelopsis grossedentata together with its main constituent, ampelopsin, were examined on D-galactosamine induced liver injury in rats. The diet containing 50% ethanolic extract (1%) and ampelopsin (0.1%) markedly suppressed the increase of LDH, ALT, AST, α-tocopherol levels and GSG/GSSH caused by GalN treatment. These results suggested that ampelopsin from Tocha acted to prevent the oxidative stress in vivo that may have been due to active oxygen species formed by a macrophage by the action of GalN.

Keywords: Ampelopsis grossedentata, ampelopsin, D-galactosamine, alanine aminotransferase, aspartate aminotransferase

Journal: BioFactors, vol. 21, no. 1-4, pp. 175-178, 2004