Affiliations: Department of Nutrition, Junior College of Tokyo
University of Agriculture, Tokyo, Japan | Department of Nutritional Science, Faculty of Applied
Bioscience, Tokyo University of Agriculture, Tokyo, Japan
Note: [] Address for correspondence: Hiroshi Matsuzaki, Department of
Nutrition, Junior College of Tokyo University of Agriculture, 1-1-1
Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan. Tel.: +81 3 5477 2573; E-mail:
[email protected]
Abstract: This study investigated the gender differences in the kidney
function of magnesium (Mg)-deficient rats. Male and female rats were fed a
control diet or a Mg-deficient diet for 21 d. Mg-deficient diet had no
significant effect on kidney calcium (Ca) or phosphorus (P) concentration in
male rats, while Ca and P concentrations in female rats were significantly
higher in Mg-deficient rats than in the control rats. With regard to indicators
of kidney function, no significant differences in creatinine clearance and
serum urea nitrogen concentration were observed among the groups. Serum albumin
concentrations were significantly lower in rats fed the Mg-deficient diet than
in rats fed the control diet. In both sexes, urinary albumin excretion was
significantly higher in rats fed the Mg-deficient diet than in rats fed the
control diet. Gender differences had no significant influence on creatinine
clearance, serum urea nitrogen concentration, serum albumin concentration and
urinary albumin excretion. These results suggest that gender differences have
no effect on kidney function in Mg-deficient rats under the condition used.
