Hepatoprotective effect of sesquiterpenes in turmeric

Issue title: The Proceedings of the 3rd International Conference on Food Factors (ICoFF 03)

Article type: Research Article

Authors: Miyakoshi, Masazumi | Yamaguchi, Yasunaga | Takagaki, Ryoji | Mizutani, Kenji | Kambara, Toshimitsu | Ikeda, Takao | Zaman, M.S. | Kakihara, Hiroki | Takenaka, Asako | Igarashi, Kiharu

Affiliations: Research Center, Maruzen Pharmaceuticals Co., Ltd. 1089-8, Sagata, Shin-ichi, Fukuyama-city, Hiroshima 729-3102, Japan | Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, 1-23 Wakaba-machi, Tsuruoka-shi, Yamagata 997-8555, Japan

Note: [] Corresponding author. Tel.: +81 847 52 5501; Fax: +81 847 52 5901; E-mail: [email protected]

Abstract: Hepatoprotective effect of turmeric together with its sesquiterpenes and curcuminoids fractions were examined on D-galactosamine induced liver injury in rats. All the diets individually contained the turmeric extract, the curcuminoids fraction, and the sesquiterpenes fraction suppressed the increase of LDH, ALT, and AST levels caused by D-GalN treatment. Since few anti-oxidative activities are expected in the sesquiterpenes fraction, it is presumed that hepatoprotective mechanism of sesquiterpenes in turmeric is different from that of curuminoids.

Keywords: turmeric, ar-turmerone, curcumin, galactosamine, alanine aminotransferase, aspartate aminotransferase

Journal: BioFactors, vol. 21, no. 1-4, pp. 167-170, 2004