Affiliations: Department of Pharmacology, St. John's Medical
College, Bangalore 560 034, India | Department of Biochemistry and Solid State &
Structural Chemistry Unit, Indian Institute of Science, Bangalore 560 012,
India
Note: [] Address for correspondence: Prof. T. Ramasarma, Department of
Biochemistry and Solid State & Structural Chemistry Unit, Indian Institute
of Science, Bangalore 560 012, India. Tel.: +91 080 334 6134 (res); +91 080 293
2309 (off); Fax: +91 080 360 0085; E-mail:
[email protected],[email protected]
Abstract: Treatment of coenzyme Q with ozone yielded a degradation product
having unmodified ring that retained its spectral characteristics and a
truncated side-chain that made it water-soluble. This derivative, but not the
intact lipid-quinone, showed relaxation of phenylephrine-contracted rat
arterial rings. This effect offers an explanation for the known hypotensive
action of exogenous coenzyme Q regardless of its side-chain length.
Keywords: coenzyme Q, ubiquinone, relaxation of arterial rings, water-soluble degradation product, BP lowering effect
Journal: BioFactors, vol. 18, no. 1-4, pp. 137-143, 2003
