Affiliations: Japan Institute for the Control of Aging (JaICA),
723-1 Haruoka, Fukuroi, Shizuoka-437-01, Japan. Tel.: +81 538 49 0125; Fax:
+81 538 49 1267 | Genox Corporation, 1414 Key Highway, Baltimore, MD
21230, USA. Tel.: +1 410 347 7616; Fax: +1 410 347 7617; E-mail:
[email protected]
Abstract: It is widely accepted that oxidative stress (OS) is a major
causative factor for many of the age-related dysfunctions and specific
diseases. Since the oxidative stress state (OSS) of an individual depends on
hereditary, dietary, and environmental factors, there is a large heterogeneity
in the population that may be related to disease incidence and longevity. Hence
there is a need to assess how well an individual is coping against OS. The
Japan Institute for the Control of Aging (JaICA) and Genox have jointly
developed a profiling technique to measure the ``Oxidative Stress Profiles
(JaICA-Genox OSP)'' of individuals and laboratory test animals. The JaICA-Genox
OSP consists of about 45 different assays measuring the levels of oxidative
damage in lipids and nucleic acids, and the antioxidant defenses in the serum.
In addition, several bio-markers for cardiovascular disease risk are also
measured, and assays to measure specific age- and sex-related hormones in the
serum and urine, and race elements in serum, urine, and drinking water are also
undertaken. This overview discusses the designing of the JaICA-Genox OSP and
its application in the testing of human subjects.
