Journal of Cellular Biotechnology - Volume Pre-press, issue Pre-press
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Electronic ISSN
2352-3697
Print ISSN
2352-3689
The
Journal of Cellular Biotechnology is a peer-reviewed international journal for advancing research activities in the field of cellular biotechnology. It serves as a medium for the publication of full papers, invited reviews, short communications, technical notes and letters to the Editor-in-Chief on all aspects of cellular biotechnology. This comprises molecular biological topics covering biochemical, chemical, pharmacological or bioprocess engineering aspects, as well as the development of novel biomaterials. Therefore, cellular biotechnology differs from biology, biochemistry, and other basic life sciences by its emphasis on using the knowledge of bioscience to solve important practical problems. Papers presenting information of a multidisciplinary nature - not suitable for publication in a journal devoted to a single discipline - are particularly welcome.
Manuscripts submitted for the
Journal of Cellular Biotechnology are expected to cover activities related to molecular diagnostics, the expansion of human primary cells for individualized therapies or drug testing, 2- and 3-dimensional co-culture techniques, cell line validation, tissue engineering, and stem cell biology for the treatment of human pathologies. This includes studies on the design of reactors and research on cellular biology and physiology of mammalian cells in vitro and in vivo, and tissue. Of special interest is the rational manipulation of reactions through metabolic engineering techniques or specific reactor operations that lead to biomaterials with unique properties. Also, biochemical and physiological studies of metabolism and enzymes as relevant for tissue culture cells, investigations at the molecular level including transcription/translation control; design and engineering of products by molecular strategies; engineering of cellular modification and transport systems such as post-translational protein modifications as well as protein and metabolite secretion; molecular strategies of screening for new or modified products (e.g. pharmaceuticals or bioactive compounds). In addition, investigations in preclinical animal experiments are welcome.
The endeavour of the Editor-in-Chief and publisher of the
Journal of Cellular Biotechnology is to bring together contributions from those working in various fields related to cell-cell or cell-material interactions all over the world. The editorial board members of the
Journal of Cellular Biotechnology are from those countries in Europe, Asia, Australia and America where appreciable work in cellular biotechnology is being carried out. Each editor takes responsibility to decide on the acceptance of a manuscript. He/she is required to have the manuscript appraised by two referees and may be one of them himself. The executive editorial office, to which the manuscripts have been submitted, is responsible for rapid handling of the reviewing process.
Abstract: BACKGROUND: The comparative understanding between cellular basis of transmission and clinical severities caused by Wuhan, Delta and Omicron strains of SARS-CoV-2 is important. OBJECTIVE: To conduct In-Vitro studies on cellular infection caused by different variants by performing cytotoxic assays and studying the live microscopic observations. METHODS: The swab samples positive for Wuhan, Delta and Omicron strains were inoculated in the Vero cell lines and their rate of infectivity and nature of cytopathy was observed. RESULTS: The study showed maximum inter cellular connectivity among cells infected by Delta variant, followed by Wuhan and least…inter cellular connections in the cells infected by Omicron variant. The Delta strain causing highest mortality as per reported epidemiological trends, showed highest inter cellular connections and maximum cell damage supporting the fastest cell to cell spread of infection and causing most mortality among patients. CONCLUSIONS: The paper reports that numerous inter cellular connections is the cause of spread of infection among cells and maximum cell damage as the cause of clinical severities. The paper sensitizes the issue that 52 subunit of viral Spike Protein could act as fusion enzyme causing the numerous inter cellular connections. Study suggests that the S2 subunit of the viral Spike Protein could be the drug target for therapeutic intervention.
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Abstract: Bone resorption is a feature of both osteoporosis and periodontitis. While, periodontitis causes localized inflammatory bone loss after an infected breach of the alveolar cortical bone and may cause tooth loss, osteoporosis causes systemic degenerative bone loss that results in loss of skeletal cancellous microstructure and eventual fracture. The majority of cross-sectional investigations have predominantly used radiographic data and to a lesser extent clinical criteria to confirm the link between osteoporosis and periodontitis. Age, heredity, hormonal changes, smoking, and a lack of calcium and vitamin D are just a few of the many common risk factors. Both disorders may have…mutual effects and may even be risk factors for one another, necessitating concurrent therapy. Disruption of the homeostasis of bone remodelling, hormone balance, and inflammation resolution are proposed processes underpinning the relationship. Emerging is a mutual interventional strategy with intricate therapeutic interactions. Both disorders urge future well-controlled longitudinal and interventional studies for evidence-based clinical guidelines and call for interdisciplinary approaches to prevention and care.
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Keywords: Osteoporosis, periodontal disease, bone remodelling
Abstract: BACKGROUND: Spirulina platensis is a well-known photosynthetic prokaryotic alga that has gained recognition in various industries, including food, health, aquaculture and pharmaceuticals. The United Nations acknowledged spirulina as a nutritious food source because of its rich pigments and high protein content. OBJECTIVE: This paper aims to provide an overview of how Spirulina is utilized as both a dietary supplement as well as functional food ingredient in the food industry. METHOD: Spirulina powder can be added to various foods such as bread, cakes and cookies to increase the nutritional value. It is particularly valuable…as a dietary supplement in efforts to combat malnutrition in impoverished regions. RESULT: Spirulina platensis is also a source of essential components used in the therapeutic microalgae supplement market. These components include alpha-carotene, astaxanthin, polyunsaturated fatty acids (such as DHA and EPA) and polysaccharides like beta-glucan. CONCLUSION: It is evident that the consumption of spirulina algae can offer both financial benefits and health advantages. Even though there is a large amount of research on the nutritional, environmental and social benefits of spirulina, some natural areas still produce insufficient amounts of the algae. As a result, more and more scientists and researchers throughout the world are pushing for the growth of spirulina farming.
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Abstract: Biologic modifiers are materials or proteins and factors that have the potential to alter the host tissue so as to stimulate or regulate the wound healing process. Classic examples of biologic modifiers are growth factors. Bioengineered materials are widely utilized due to their biocompatibility and degradability, as well as their moisturizing and antibacterial properties. One field of their application in medicine is to treat wounds by promoting tissue regeneration and improving wound healing. In addition to creating a physical and chemical barrier against primary infection, the mechanical stability of the porous structure of biomaterials provides an extracellular matrix (ECM)-like niche…for cells. Growth factors are polypeptide molecules that control the growth, differentiation, and metabolism of cells during each of the three phases of wound healing. They are present throughout the body in only minute concentrations yet exert a powerful local influence on wound repair. They interact with specific receptors in the cell surface, leading to specific responses determined by the receptor-mediated signal transduction pathways within the target cells. Growth factors (GFs) and cytokines, which are secreted by the cells, are essential parts of the complex process of tissue regeneration and wound healing.
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Abstract: In recent years, induced pluripotent stem cells (iPSCs) have emerged as a transformative force in regenerative medicine, offering unprecedented opportunities for advancements in various fields. This review explores the revolutionary impact of iPSCs specifically within the realm of dentistry, where regenerative strategies are increasingly sought to address oral and craniofacial tissue defects. iPSCs, derived from somatic cells through reprogramming, exhibit pluripotency and can differentiate into various cell types, including dental-specific lineages such as odontoblasts, ameloblasts, and osteoblasts. The application of iPSCs in dentistry holds immense promise for tissue repair, regeneration, and disease modelling. This review delves into the key aspects…of iPSC-based approaches in dental research, covering topics such as tooth regeneration, periodontal tissue engineering, and craniofacial defect repair. We discuss the challenges and advancements in iPSC technology, emphasizing the potential for personalized regenerative therapies tailored to individual patients.
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