Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Nallapu, Bhargav T.a; * | Petersen, Kellen K.a | Lipton, Richard B.a | Grober, Ellena | Sperling, Reisa A.b; c | Ezzati, Alia
Affiliations: [a] Saul B. Korey Department of Neurology, Albert Einstein College of Medicine, New York City, NY, USA | [b] Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA | [c] Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA
Correspondence: [*] Correspondence to: Bhargav T. Nallapu, PhD, Department of Neurology, Albert Einstein College of Medicine, Van Etten 3C12, 1300 Morris Park Avenue, Bronx, NY 10461, USA. Tel.: +1 718 430 3896; E-mail:[email protected].
Abstract: Background:Alcohol use disorders have been categorized as a ‘strongly modifiable’ risk factor for dementia. Objective:To investigate the cross-sectional association between alcohol consumption and cognition in older adults and if it is different across sexes or depends on amyloid-β (Aβ) accumulation in the brain. Methods:Cognitively unimpaired older adults (N = 4387) with objective and subjective cognitive assessments and amyloid positron emission tomography (PET) imaging were classified into four categories based on their average daily alcohol use. Multivariable linear regression was then used to test the main effects and interactions with sex and Aβ levels. Results:Individuals who reported no alcohol consumption had lower scores on the Preclinical Alzheimer Cognitive Composite (PACC) compared to those consuming one or two drinks/day. In sex-stratified analysis, the association between alcohol consumption and cognition was more prominent in females. Female participants who consumed two drinks/day had better performance on PACC and Cognitive Function Index (CFI) than those who reported no alcohol consumption. In an Aβ-stratified sample, the association between alcohol consumption and cognition was present only in the Aβ– subgroup. The interaction between Aβ status and alcohol consumption on cognition was not significant. Conclusion:Low or moderate consumption of alcohol was associated with better objective cognitive performance and better subjective report of daily functioning in cognitively unimpaired individuals. The association was present only in Aβ– individuals, suggesting that the pathophysiologic mechanism underlying the effect of alcohol on cognition is independent of Aβ pathology. Further investigation is required with larger samples consuming three or more drinks/day.
Keywords: Alcohol, Alzheimer’s disease, amyloid PET, cognition, sex differences
DOI: 10.3233/JAD-221079
Journal: Journal of Alzheimer's Disease, vol. 93, no. 4, pp. 1381-1393, 2023
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]