Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Cheng, Yong | Yu, Long-Chuan; *
Affiliations: Neurobiology Laboratory and National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, People's Republic of China
Correspondence: [*] Correspondence to: Long-Chuan Yu, Neurobiology Laboratory and National Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, People's Republic of China. Tel.: +86 10 6275 3667; Fax: +86 10 6275 1526; E-mail: [email protected].
Note: [] Handling Associate Editor: Shengdi Chen
Abstract: The neuropeptide galanin and its receptors are found to be upregulated in brain associated with Alzheimer's disease (AD), while the role of galanin in AD is still unclear. The present study was performed to explore the neuroprotective role of galanin both in vitro and in vivo. Our results demonstrated that galanin inhibited the neurotoxicity induced by amyloid-β25-35 (Aβ25-35) or Aβ1-42 in primary cultured hippocampal neurons of rats. Moreover, Gal2-11 (an agonist of GalR2/3) also inhibited the neurotoxicity induced by Aβ25-35 in the cultured neurons. We further found that galanin inhibited the activation of p53, Bax, and caspase-3 induced by Aβ25-35 in the cultured hippocampal neurons. Moreover, galanin reversed the down regulation of Bcl-2 induced by Aβ25-35 in the cultured neurons. Interestingly, in the Morris water maze task we found that intra-CA1 injection of Aβ25-35-induced spatial learning deficits in rats were blocked by galanin. In addition, galanin inhibited the Aβ25-35-induced dysregulation of p53, Bax, and MAP2 in rat hippocampus. Our results strongly demonstrate that galanin plays neuroprotective roles in nerve cells and in AD-induced learning and memory deficits.
Keywords: Amyloid-β, Bax, Bcl-2, caspase-3, Gal2-11, galanin, galanin receptor 2, hippocampal neuron, MAP2, Morris water maze, neuroprotective effect, p53
DOI: 10.3233/JAD-2010-091234
Journal: Journal of Alzheimer's Disease, vol. 20, no. 4, pp. 1143-1157, 2010
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
[email protected]
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office [email protected]
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
[email protected]
For editorial issues, like the status of your submitted paper or proposals, write to [email protected]
如果您在出版方面需要帮助或有任何建, 件至: [email protected]