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Is the Glut expression related to FDG uptake in PET/CT of non-small cell lung cancer patients?

Issue title: Papers from the 3rd International Conference on Biomedical Engineering and Technology (iCBEB 2014), 25–28 September 2014, Beijing, China

Subtitle:

Guest editors: Edward J. Ciaccio

Article type: Research Article

Authors: Choi, Woo Heea | Yoo, Ie Ryungb; * | O, Joo Hyunb | Kim, Tae Jungc | Lee, Kyo Youngd | Kim, Young Kyoone

Affiliations: [a] Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea | [b] Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea | [c] Department of Hospital Pathology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea | [d] Department of Hospital Pathology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea | [e] Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Correspondence: [*] Corresponding author: Ie Ryung Yoo, Department of Radiology, Seoul St. Mary's Hospital, Seocho-gu, Banpo-dong 505, Seoul 137-701, Korea. Tel.: +82 2 2258 1552; Fax: +82 2 2258 1575; E-mail:[email protected]

Keywords: Glut-1, Glut-3, glucose transporter, FDG, non-small cell lung cancer

DOI: 10.3233/THC-150967

Journal: Technology and Health Care, vol. 23, no. s2, pp. S311-S318, 2015

Published: 2015
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Abstract

Though18F-FDG PET/CT scans are widely used in non-small cell lung cancer (NSCLC), the mechanism of FDG uptake by lung cancer cells has not yet been fully elucidated. This study evaluated the relationship between FDG uptake and the expression of glucose transporters in NSCLC. Sixty-four NSCLC patients who underwent both preoperative18F-FDG PET/CT scanning and thoracotomy were included. The maximum standardized uptake value (SUVmax) of the primary lung cancer was compared to the immunohistochemistry results for Glut expression and tumor size. In all the NSCLC cases, degree of FDG uptake significantly correlated with both Glut-1 and Glut-3 expression. When stratified by the histology, squamous cell carcinomas showed higher mean SUVmax, Glut-1 expression intensity, and percentage of area positive for Glut-1 expression than adenocarcinomas. Glut-1 and Glut-3 expressions correlated with SUVmax in adenocarcinomas, but there was no significant correlation in squamous cell carcinomas. No significant correlation was observed between tumor size and FDG uptake or Glut expression. These results show that Glut expression was significantly correlated with SUVmax in NSCLC, especially in adenocarcinomas, and that neither FDG uptake nor the expression of Glut was associated with tumor size.

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