Affiliations: [a] Department of Pharmacy, Zunyi Medical College, Zunyi, Guizhou, China | [b] School of Pharmaceutical and Biological Engineering, Sichuan University, Chengdu, Sichuan, China
Abstract: This research aimed to compare antioxidant and anticancer
activities of the essential oil from various habitats of Selaginella doederleinii Hieron. The results
showed that antioxidative activities of the essential oil were the best from
Guizhou province in 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging,
2,2'-azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) radical
scavenging, ferric reducing and ferric reducing antioxidant power (FRAP),
while those of the essential oil from Sichuan province were the weakest
among different habitats. The anticancer results showed that antitumor
effects of the essential oil from Guizhou province were the best against A549
cell line and 7721 cell line, while those of the essential oil from Sichuan
province were the weakest among different habitats. Proliferative and
antioxidant activities were correlated. The correlation coefficients
(R2) between antioxidant and anticancer capacities varied from 0.71 to
0.94. The results of tests indicated that the antioxidant and
anticancer activities of the essential oil from various habitats were great
differences that might be affected by environmental variation, harvest
seasons and so on. Investigation in vitro revealed that the essential
oil of S. doederleinii were found to be effective in suppressing the oxidative
activity and proliferation of cancer cells. This experiment provides scientific
foundation for further utilization of S. doederleinii.
