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Issue title: Special Section: Enabling Technologies for Healthcare 5.0
Guest editors: Chi Lin, Chang Wu Yu and Ning Wang
Article type: Research Article
Authors: Li, Xiaa | Dong, Lilib; *
Affiliations: [a] Thyroid and Breast Surgery Department, The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, China | [b] Thyroid and Breast Surgery Department, The First People’s Hospital of Lianyungang (The First Affiliated Hospital of Kangda College of Nanjing Medical University), Lianyungang, Jiangsu, China
Correspondence: [*] Corresponding author: Lili Dong, Thyroid and Breast Surgery Department, The First People’s Hospital of Lianyungang (The First Affiliated Hospital of Kangda College of Nanjing Medical University), Lianyungang, Jiangsu, China. E-mail: [email protected].
Abstract: BACKGROUND: Breast cancer (BC) is one of the most common malignancies in women and imposes a significant health burden globally. According to data from the World Health Organization, the incidence of BC has been increasing steadily over the years. It has become one of the leading causes of cancer-related death among women worldwide. OBJECTIVE: This work was to evaluate the combined intervention effect of psychological care along with the use of ondansetron, dexamethasone, and promethazine hydrochloride in breast cancer (BC) patients undergoing chemotherapy, including their impact on nausea and vomiting control, quality of life (QoL), and psychological status. METHODS: 64 BC patients undergoing chemotherapy were collected and randomly rolled into a control group (Group C) and an intervention group (Group I). Group C received ondansetron combined with routine psychological support and counseling therapy, while Group I received a combination of ondansetron, dexamethasone, promethazine hydrochloride, and psychological care therapy. Self-assessment scores for anxiety, QoL ratings, white blood cell counts, and incidence of adverse reactions were assessed and compared between the two groups. RESULTS: Group I showed better control of nausea and vomiting versus Group C (P< 0.05). Marked improvements were also observed in the self-rating anxiety scale (SAS) scores, white blood cell counts, and nursing satisfaction in Group I versus Group C (P< 0.05). Nevertheless, the two groups had no significant difference regarding QoL scores (P> 0.05). CONCLUSION: the combination of psychological care with ondansetron, dexamethasone, and promethazine hydrochloride effectively controls nausea and vomiting symptoms in BC patients undergoing chemotherapy and provides higher levels of clinical nursing satisfaction.
Keywords: Chemotherapy for breast cancer, psychological nursing, ondansetron, dexamethasone, promethazine hydrochloride
DOI: 10.3233/THC-240695
Journal: Technology and Health Care, vol. 32, no. 6, pp. 5047-5063, 2024
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