Correlation analysis of hypertension, traditional Chinese medicine constitution, and LPL gene polymorphism in the elderly in communities in Shanghai

Article type: Research Article

Authors: Tao, Ying^{a; b; 1} | Jiang, Li-Ming^{c; 1} | Zhou, Chang^a | Lin, Yun-Xiao^a | Yang, Yan-Qing^{b; *} | Wang, You-Hua^{a; *}

Affiliations: [a] Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China | [b] Department of Traditional Chinese Medicine, Shanghai Pudong New Area Puxing Community Health Service Center, Shanghai, China | [c] Department of Rehabilitation, Seventh People’s Hospital of Shanghai University of Traditional Chinese Medicine, Shanghai, China

Correspondence: [*] Corresponding authors: You-Hua Wang, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, No. 725, South Wanping Road, Xuhui District, Shanghai 200032, China. E-mail: [email protected]. Yan-Qing Yang, Department of Traditional Chinese Medicine, Shanghai Pudong New Area Puxing Community Health Service Center, No. 250, Guichang Road, Pudong New District, Shanghai 200136, China. E-mail: [email protected].

Note: [1] These authors contributed equally to this study.

Abstract: BACKGROUND: Research on the genetic mechanisms of hypertension has been a hot topic in the cardiovascular field. OBJECTIVE: To study the correlation between senile hypertension and traditional Chinese medicine (TCM) constitution and lipoprotein lipase (LPL) gene polymorphism and to provide the theoretical basis for TCM prevention and treatment of hypertension. METHODS: The elderly population in communities in Shanghai (hypertensive: 264 cases; non-hypertensive: 159 cases) was taken as the research object. Essential data and information on TCM constitution were collected. The LPL gene mutation was detected using the second-generation sequencing method. Statistical analysis was performed to clarify the relationship between hypertension and senile hypertension. The correlation of TCM constitution with risk factors and LPL gene polymorphisms was studied. RESULTS: The primary TCM constitutions in the hypertension group were phlegm-dampness constitution (51.52%), yin-deficiency constitution (17.42%), balanced constitution (15.53%), and yin-deficiency (9.43%). Logistic regression analysis showed that the phlegm-dampness constitution (P< 0.05, OR = 2.587) and yin-deficiency constitution (P< 0.01, OR = 2.693) were the risk constitutions of hypertension in the elderly. A total of 37 LPL gene mutation loci (SNP: 22; new discovery: 15) were detected in the LPL gene, and the mutation rates of rs254, rs255, rs3208305, rs316, rs11570891, rs328, rs11570893, and rs13702 were relatively high, which were 26.24%, 26.24%, 16.08%, 14.66%, 13.24%, 12.06%, and 10.64%. In the phlegm-dampness group, the proportion of rs254 CC type, rs255 TT type, and rs13702 TT type in the hypertensive group (77.21%, 77.21%, and 93.38%) was higher than that in the non-hypertensive group (56.41%, 56.41%, and 82.05%), The difference was statistically significant (P< 0.05). CONCLUSION: The phlegm-dampness constitution and yin-deficiency constitution are the risk factors of hypertension in the elderly; in the phlegm-dampness population, rs254 CC type, rs255 TT type, and rs13702 TT type are the risk factors for elderly hypertension.

Keywords: Elderly, hypertension, LPL gene, TCM constitution

DOI: 10.3233/THC-220908

Journal: Technology and Health Care, vol. 32, no. 1, pp. 255-267, 2024