Affiliations: [a] Department of Diagnostic Imaging, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan | [b] Graduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Maebashi, Japan | [c] Department of Neurology, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, Isesaki, Japan | [d] Department of Radiological Technology, Gunma Prefectural College of Health Sciences, Maebashi, Japan
Correspondence:
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Corresponding author: Ryuya Okawa, Department of Diagnostic Imaging, Institute of Brain and Blood Vessels, Mihara Memorial Hospital, 366 Otamachi, Isesaki, Gunma 372-0006, Japan. E-mail: [email protected].
Abstract: BACKGROUND: The failure of cerebrospinal fluid (CSF) signal suppression in postmortem fluid-attenuated inversion recovery (FLAIR) of the brain is a problem. OBJECTIVE: The present study was to clarify the relationship between the temperature of deceased persons and CSF T1, and to optimize the postmortem brain FLAIR imaging method using synthetic MRI. METHODS: Forehead temperature was measured in 15 deceased persons. Next, synthetic MRI of the brain was performed, the CSF T1 was measured, and the optimal TI was calculated. Two types of FLAIR images were obtained with the clinical and optimal TI. The relationship between forehead temperature and the CSF T1 and optimal TI was evaluated. The optimized FLAIR images were physically and visually evaluated. RESULTS: The CSF T1 and optimal TI were strongly correlated with forehead temperature. Comparing the average SNR and CNR ratios and visual evaluation scores of the two FLAIR images, those captured with the optimal TI showed statistically lower SNR, higher CNR, and higher visual evaluation scores (p< 0.01). CONCLUSIONS: Synthetic MRI enables the quantification of the CSF T1 resulting from postmortem temperature decreases and calculation of the optimal TI, which could aid in improving the failure of CSF signal suppression and in optimizing postmortem brain FLAIR imaging.
Keywords: Synthetic magnetic resonance imaging, autopsy imaging, inversion time, cerebrospinal fluid, fluid-attenuated inversion recovery
