Resomer C212© in vertebroplasty or kyphoplasty: A feasibility study on artificial bones with biomechanical and thermal evaluation

Article type: Research Article

Authors: Greiner, Axel^a | Bongartz, Anne^a | Woiczinski, Matthias^b | Befrui, Nima^a | Pieske, Oliver^c | Suero, Eduardo M.^a | Bruder, Jan^a | Kammerlander, Christian^a | Böcker, Wolfgang^a | Becker, Christopher A.^{a; *}

Affiliations: [a] Department of General Trauma & Reconstructive Surgery, University Hospital, LMU Munich, Munich, Germany | [b] Department of Orthopedics, Physical Medicine and Rehabilitation, University Hospital, LMU Munich, Munich, Germany | [c] Department of Traumatology & Orthopedic Surgery, Cath. Hospital, Oldenburg, Germany

Correspondence: [*] Corresponding author: Christopher A. Becker, Department of General Trauma & Reconstructive Surgery, University Hospital, LMU Munich, Marchioninistraße 15, D-81377 Munich, Germany. Tel.: +49 89 4400 0; E-mail: [email protected].

Abstract: BACKGROUND: Vertebroplasty and kyphoplasty are now well-established methods for treating compression fractures of vertebral bodies (AO type A) as well as vertebral body metastases [1, 2, 3]. However, polymethylmethacrylate (PMMA) augmented vertebrae show fractures of subsequent vertebral bodies due to the increased stability of the augmented vertebral body [4]. Resorbable cements are currently only used experimentally. Many commercially available resorbable calcium phosphate cements do not exhibit sufficient biomechanical stability to treat vertebral body fractures [5]. Resomer C212© (Evonik Industries AG, Essen, Germany) is a slow resorbable poly-ε-caprolactone that has low melting temperatures and good biomechanical properties. OBJECTIVE: This is a feasibility study on how the poly-ε-caprolactone Resomer C212© can be used for kypho- or vertebroplasty, what temperatures are used in the argumentation and how differences in load capacity are measurable compared to conventional PMMA cement. METHODS: 23 Sawbones© blocks (7.5 Open Cell Foam, SKU: 1522-09, laminated on both sides, 4 × 4 × 2.9 cm, Sawbones, Vashon Island, USA) were divided into three groups: 7 without augmentation, 8 augmented with PMMA cement Traumacem V+© (DePuy Synthes, West Chester, USA) and 8 augmented with Resomer C212©. Temperature measurements were made in a 37∘C water bath centrally in the block and on the top and bottom plates. This was followed by a maximum load of up to 2000 N using a universal testing machine (Instron E 10000, Instron Industrial Products, Grove City, USA). RESULTS: In the Resomer C212© test group, the maximum average increase in temperature was 4.15 ± 4.72∘C central, 0.3 ± 0.31∘C at the top and 0.78 ± 1.27∘C at the base. In the cement test group, the average increase in temperature was 9.80 ± 10.65∘C centrally in the test block, 1.50 ± 0.73∘C at the top plate and 1.42 ± 0.66∘C and the base plate. In the axial compression test, the 7 non-kyphoplasted test blocks showed a first loading peak on average at 275.23 ± 80.98 N, a rigidity of 238.47 ± 71.01 N/mm2. In the Traumacem V+© group, the mean peak load was 313.72 ± 46.26 N and rigidity was 353.45 ± 77.23 N/mm2. The Resomer C212© group achieved a peak load of 311.74 ± 52.05 N and a stiffness of 311.30 ± 126.63 N/mm2. A compression to 50% could not be seen in any test block under the load of 2000 N. At 2000 N, Traumacem V+©’s average height reduction was 9.26 ± 2.16 mm and Resomer C212© was 10.93 ± 0.81 mm. CONCLUSIONS: It has been shown that the application of Resomer C212© in kyphoplasty or vertebroplasty is well feasible. Thermal analysis showed significantly lower temperatures and shorter temperature application in the Resomer C212© group. In the biomechanical load up to 2000 N no significant differences could be observed between the individual groups.

Keywords: Kyphoplasty, resomer, resorbable, vertebral fracture, biomechanics

DOI: 10.3233/THC-202159

Journal: Technology and Health Care, vol. 29, no. 2, pp. 343-350, 2021