Affiliations: CRC Clinical Magnetic Resonance Research Group, Institute of Cancer Research and Royal Marsden Hospital, Downs Road Sutton, Surrey, SM2 5PT, UK | [1] Laboratory of Cell Biology, Istituto Superiore di Sanita, Rome, Italy | [2] CRC Clinical Magnetic Resonance Group, The Institute of Cancer Research and the Royal Marsden NHS Trust, Sutton, Surrey, UK
Abstract: Magnetic resonance spectroscopy provides a means of non-invasively measuring the behaviour of a range of compounds of biochemical significance. With the development of a range of spatial localization and mapping techniques, the method has a range of promising applications in oncology. 31P and 1H spectroscopy are of value in observing the metabolism of both tumours and normal tissues. 19F spectroscopy has been used to monitor the metabolism of fluorine containing anticancer drugs, and 13C may find application in this field, particularly in pre-clinical studies. In vivo clinical measurements are complemented by pre-clinical studies, high resolution measurements of extracts from tissue samples and also the measurement of biofluids, which can provide additional metabolic and pharmacokinetic information. The application of these techniques to oncology is reviewed, with particular emphasis on their clinical role.
Keywords: Nuclear magnetic resonance, Spectroscopy, Cancer, Clinical studies, Cancer therapy
