Experimental investigation of the determination for the safe operating regime of ultrasound tube-shaped waveguide wire for internal blood vessel debulking

Issue title: Advances in Biomedical Engineering: Research that bridges the gap between Engineering and Medicine

Guest editors: Julius Griškevičius.

Article type: Other

Authors: Bubulis, Algimantas^a | Venslauskas, Mantas^a | Navickas, Jonas^a | Abramavičius, Silvijus^{b; *} | Stankevičius, Edgaras^b

Affiliations: [a] Institute of Mechatronics, Kaunas University of Technology, Kaunas, Lithuania | [b] Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania

Correspondence: [*] Corresponding author: Silvijus Abramavicius, Institute of Physiology and Pharmacology, Lithuanian University of Health Sciences, A. Mickeviciaus str. 9, Kaunas LT-44307, Lithuania. Tel.: +370 68644690; E-mail: [email protected].

Abstract: BACKGROUND: Majority of limb amputations are caused by circulatory disturbances such as vascular occlusions and strictures. Discovery of modern and more advanced ultrasonic interventional vascular debulking methodology would likely save limbs of CVD patients and their lives in an economical way. However, there is a lack of researches regarding the ultrasound’s effect on physiological functions of human blood cells. The tube-shaped ultrasound waveguide wire with orifices at its operational end was offered as the alternative to some currently patented interventional thrombosis treatment solutions. OBJECTIVE: To establish the safe operating regime of the proposed device. METHODS: The temperature rise induced by the cavitation process and friction between the waveguide and surrounding fluids was measured and microscopic pictures of human blood were made. RESULTS: Blood insonation lasting 15 seconds, leads to blood clot formation. If insonation continues for 30 seconds some cells are totally destroyed. In addition, the safe operating regime was established. To avoid heating of the environment to the temperature harmful for the medium (blood) and surrounding tissues, is achieved when the system should be on for 40%, and of for 60% of the period of 1 second. CONCLUSIONS: The safe operating regime of the proposed device was established.

Keywords: Cavitation, ultrasound, peripheral artery disease, cardiovascular diseases

DOI: 10.3233/THC-182509

Journal: Technology and Health Care, vol. 26, no. S2, pp. 625-634, 2018