Affiliations: [a] Shanghai University of Medicine and Health Sciences, Shanghai 201318, China | [b] College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China | [c] Shanghai MAXAM Company Limited, Shanghai 200333, China | [d] Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Huaihai Institute of Technology, Lianyungang 222005, Jiangsu, China | [e] Department of Food Science, Cornell University, Ithaca 14853-7201, NY, USA | [f] Laboratory of Quality and Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture, Shanghai 201306, China
Correspondence:
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Corresponding authors: Bin Bao and Ming Ma, College of Food Science and Technology, Shanghai Ocean University, No. 999 Hucheng Ring Road, Pudong New Area, Shanghai 201306, China. Tel./Fax: +86 021 6190 0388; E-mail: [email protected], [email protected].
Abstract: BACKGROUND: Periodontitis is a chronic inflammatory disease caused by Porphyromonas gingivalis that leads to a series of periodontal tissue injuries. Egg yolk immunoglobulins (IgY) is procuded in egg yolk and inhibits P. gingivalis. OBJECTIVE: The aim was to evaluate the effect of IgY on experimental periodontitis caused by P. gingivalis. METHODS: The second molars of rats were ligatured using medical 5-0 silk and smeared with P. gingivalis to induce experimental periodontitis. Then, the rats were smeared with 2 mL IgY solutions or 0.9% NaCl in the oral cavity for up to 4 wk. The scores for gingival index, plaque index and probe on bleeding, the levels of IL-6 and TNF-α, X-ray radiography and histology were used to determine the efficacy of the IgY on experimental periodontitis. RESULTS: The clinical indices improved; the levels of IL-6 and TNF-α were significantly (p< 0.05) decreased; the X-rays and histomorphological observations suggested that the periodontal inflammation and periodontitis were alleviated compared to the control. CONCLUSIONS: IgY showed significant effects on anti-inflammatory, anti-coaggregation activity, and protected against alveolar bone loss. Therefore, it had a beneficial effect on preventing experimental periodontitis caused by P. gingivalis.
