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Variability of hemodynamic parameters using the common viscosity assumption in a computational fluid dynamics analysis of intracranial aneurysms

Article type: Research Article

Authors: Suzuki, Takashia | Takao, Hiroyukia; b; c; * | Suzuki, Takamasad | Suzuki, Tomoakib | Masuda, Shunsukeb | Dahmani, Chihebeddineb; e | Watanabe, Mitsuyoshib | Mamori, Hiroyaf | Ishibashi, Toshihirob | Yamamoto, Hidekid | Yamamoto, Makotof | Murayama, Yuichib

Affiliations: [a] Graduate School of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan | [b] Division of Endovascular Neurosurgery, Department of Neurosurgery, The Jikei University School of Medicine, Tokyo, Japan | [c] Department of Innovation for Medical Information Technology, The Jikei University School of Medicine, Tokyo, Japan | [d] Department of Chemical, Energy and Environment Engineering, Kansai University, Osaka, Japan | [e] Siemens Japan K.K., Shinagawa-ku, Tokyo, Japan | [f] Department of Mechanical Engineering, Tokyo University of Science, Tokyo, Japan

Correspondence: [*] Corresponding author: Hiroyuki Takao, Division of Endovascular Neurosurgery, Department of Neurosurgery, The Jikei University School of Medicine, 3-25-8 Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan. Tel.: +81 3 3433 3461; Fax: +81 3 3459 6412; E-mail:[email protected]

Keywords: Computational fluid dynamics, intracranial aneurysm, viscosity, non-Newtonian viscosity, wall shear stress, Casson model

DOI: 10.3233/THC-161245

Journal: Technology and Health Care, vol. 25, no. 1, pp. 37-47, 2017

Received 10 February 2016
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Accepted 2 June 2016
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Published: 21 February 2017
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Abstract

BACKGROUND:

In most simulations of intracranial aneurysm hemodynamics, blood is assumed to be a Newtonian fluid. However, it is a non-Newtonian fluid, and its viscosity profile differs among individuals. Therefore, the common viscosity assumption may not be valid for all patients.

OBJECTIVE:

This study aims to test the suitability of the common viscosity assumption.

METHODS:

Blood viscosity datasets were obtained from two healthy volunteers. Three simulations were performed for three different-sized aneurysms, two using measured value-based non-Newtonian models and one using a Newtonian model. The parameters proposed to predict an aneurysmal rupture obtained using the non-Newtonian models were compared with those obtained using the Newtonian model.

RESULTS:

The largest difference (25%) in the normalized wall shear stress (NWSS) was observed in the smallest aneurysm. Comparing the difference ratio to the NWSS with the Newtonian model between the two Non-Newtonian models, the difference of the ratio was 17.3%.

CONCLUSIONS:

Irrespective of the aneurysmal size, computational fluid dynamics simulations with either the common Newtonian or non-Newtonian viscosity assumption could lead to values different from those of the patient-specific viscosity model for hemodynamic parameters such as NWSS.

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