Endoscopic low-temperature plasma radiofrequency ablation for laryngeal plexiform neurobromatosis-1 in an infant: Case report and review of the literature

Article type: Brief Report

Authors: Wang, Zhinan^* | Zhang, Yamin | Cui, Hua | Yao, Wei

Affiliations: Department of Otorhinolaryngology, Wuhan Medical & Healthcare Center for Women and Children (Wuhan Children's Hospital Wuhan Women and Children Care Hospital), Wuhan, Hubei, China

Correspondence: [*] Corresponding author: Zhinan Wang, Department of Otorhinolaryngology, Wuhan Children's Hospital, No. 100 Hongkong Road, Jiang'an District, Wuhan 430016, Hubei, China. Tel.: +86 18907121642; Fax: +86 02782423687; E-mail:[email protected]

Abstract: To evaluate the feasibility and effectiveness of using endoscopic low-temperature plasma radiofrequency ablation (RFA) for treatment of laryngeal plexiform neurofibromatosis-1 (NF-1). An infant diagnosed as laryngeal plexiform NF-1 based on a detailed medical history, as well as physical, laboratory, and pathological examinations, was treated under general anesthesia with low-temperature plasma RFA in combination with a self-retaining laryngoscope and high definition camera system. The laryngeal plexiform NF-1 tumor was successfully excised using endoscopic low-temperature plasma RFA without complications. Following surgery, the infant displayed an uneventful recovery and no disease recurrence during a 2-year follow-up period. low-temperature plasma RFA is a feasible and effective method for treating laryngeal plexiform NF-1, and has advantages of producing minimal bleeding, providing complete removal of the tumor, and causing only slight degrees of trauma and postoperative tissue reaction.

Keywords: Neurofibromatosis, laryngeal plexiform neurofibromatosis type-1, laryngemphraxis, low-temperature plasma radiofrequency ablation

DOI: 10.3233/THC-161218

Journal: Technology and Health Care, vol. 24, no. 5, pp. 775-780, 2016