You are viewing a javascript disabled version of the site. Please enable Javascript for this site to function properly.
Go to headerGo to navigationGo to searchGo to contentsGo to footer
In content section. Select this link to jump to navigation

Construction of an anthropopathic abdominal phantom for accuracy validation of deformable image registration

Issue title: Papers from the 4th International Conference on Biomedical Engineering and Biotechnology (ICBEB2015), 18-21 August 2015, Shanghai, China ``New Paradigms for Biomedical Engineering and Biotechnology''

Article type: Research Article

Authors: Liao, Y.L. | Chen, H.B. | Zhou, L.H.* | Zhen, X.*

Affiliations: Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China

Correspondence: [*] Corresponding authors: L.H. Zhou and X. Zhen, Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China. E-mail:[email protected](LZ),[email protected](XZ)

Keywords: Three-dimensional deformable phantom, deformable image registration, PVC, phantom construction

DOI: 10.3233/THC-161200

Journal: Technology and Health Care, vol. 24, no. s2, pp. S717-S723, 2016

Published: 13 June 2016
Get PDF open access

Abstract

The purpose of this study is to design and fabricate an anthropopathic abdominal phantom for accuracy evaluation of deformable image registration (DIR) algorithms in adaptive radiation therapy. The constructed deformable organs, including the liver, kidney, spleen and stomach, are made of mixture of polyvinyl chloride (PVC) and softener dioctyl terephthalate, while the rigid structures, i.e. vertebrae, are made of white cement. Relation between the PVC-softener blending ratio and organ CT number is studied, and three-dimensional printing technic is employed to create highly anthropopathic organs in terms of organ shape and density. Detailed steps for phantom construction, landmark point placement and choice of phantom ingredients and construction recipe are introduced. Preliminary results of the mechanical properties of the fabricated organs are also presented. The experimental results indicate that the constructed phantom has satisfactory elastic characteristics and close CT number with corporal organs, and can potentially be applied to simulate real abdominal organ deformation in geometric accuracy validation of DIR algorithms.

References

[1] 

Kirby N., , Chuang C., and Pouliot J., A two-dimensional deformable phantom for quantitatively verifying deformation algorithms. Med Phys 38: , 4583 ((2011) ).

[2] 

Graves Y.J., , Smith A., , Mcilvena D., , Manilay Z., , Lai Y.K., , Rice R., , Mell L., , Jia X., , Jiang S.B., and Cerviño L., A deformable head and neck phantom with in-vivo dosimetry for adaptive radiotherapy quality assurance. Med Phys 42: , 1490 ((2015) ).

[3] 

Singhrao K., , Kirby N., and Pouliot J., A three-dimensional head-and-neck phantom for validation of multimodality deformable image registration for adaptive radiotherapy. Med Phys 41: , 121709 ((2014) ).

[4] 

Kashani R., , Hub M., , Kessler M.L., and Balter J.M., Technical note: A physical phantom for assessment of accuracy of deformable alignment algorithms. Med Phys 34: , 2785 ((2007) ).

[5] 

Kashani R., , Lam K., , Litzenberg D., and Balter J., Technical note: A deformable phantom for dynamic modeling in radiation therapy. Med Phys 34: , 199 ((2007) ).

[6] 

Chang J., , Suh T.S., and Lee D.S., Development of a deformable lung phantom for the evaluation of deformable registration. J Appl Clin Med Phys 11: , 3081 ((2010) ).

[7] 

Hungr N., , Long J., , Beix V., and Troccaz J., A realistic deformable prostate phantom for multimodal imaging and needle-insertion procedures. Med Phys 39: , 2031 ((2012) ).

[8] 

Serban M., , Heath E., , Stroian G., , Collins D.L., and Seuntjens J., A deformable phantom for 4D radiotherapy verification: Design and image registration evaluation. Med Phys 35: , 1094 ((2008) ).

[9] 

Lorensen W.E., and Cline H.E., Marching cubes: A high resolution 3D surface construction algorithm. SIGGRAPH Comput. Graph. 21: , 163 ((1987) ).

[10] 

Yeo U.J., , Taylor M.L., , Dunn L., , Kron T., , Smith R.L., and Franich R.D., A novel methodology for 3D deformable dosimetry. Med Phys 39: , 2203 ((2012) ).

[11] 

Niu C.J., , Foltz W.D., , Velec M., , Moseley J.L., , Al-Mayah A., and Brock K.K., A novel technique to enable experimental validation of deformable dose accumulation. Med Phys 39: , 765 ((2012) ).

Show more