Affiliations: [a] Department of Medical Biotechnology, Dongguk University-Bio Medi Campus, Gyeonggi-do, Korea | [b] Department of Medical Devices Industry, Dongguk University-Seoul, Seoul, Korea
Correspondence:
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Corresponding author: Sung Min Kim, Department of Medical Biotechnology, Dongguk University-Bio Medi Campus, 32, Dongguk-ro, Ilsan Dong-gu, Goyang-si, Gyeonggi-do, Korea. E-mail:[email protected]
Abstract: This study measured epidermal and dermal temperatures
under different cryogen spray cooling (CSC) conditions to determine the
optimum cooling conditions for skin rejuvenation. For this purpose, CSC
conditions were applied before a laser transmission for varying spurt times
of 50, 150, and 200 ms with delay times of 150 and 200 ms. A long-pulsed
1,064 nm Nd:YAG laser irradiated the skin surface of a pig with a condition
of fluence of 26 J/cm2 and a spot diameter of 8 mm. The pulse duration
was set to 30 ms during all experiments. This study found that all employed
CSC conditions significantly decreased internal-external skin temperatures.
Moreover, skin temperatures were influenced more by variations in spurt time
of CSC compared with the delay times. Based on these experimental results,
two spurt times were selected as the optimum CSC conditions for skin
rejuvenation: 50 ms with delay time of 150 and 200 ms and 150 ms with a
delay time of 150 and 200 ms.
