Miniaturized integrated biosensors

Article type: Research Article

Authors: Urban, G.^{; *} | Jobst, G. | Keplinger, F. | Aschauer, E. | Fasching, R. | Svasek, P.

Affiliations: Institut für allgemeine Elektrotechnik und Elektronik, L. Boltzmann-Institut für biomedizinische Mikrotechnik and Hirnkreislaufforschung. Technical University Vienna, Gußhausstr. 27, 1040 Vienna, Austria

Correspondence: [*] Corresponding author, Tel.: +43-1-58801-3672, Fax: +43-1-5042477.

Abstract: Miniaturized integrated thin-film biosensors were developed for use in clinical analyzers and for in vivo applications. A glucose and a lactate sensor were integrated with a pH-sensor on a flexible substrate. Both enzyme sensors are based on the electrochemical measurement of H2O2 produced by the enzymes glucoseoxidase and lactateoxidase respectively. The solid state pH-sensor uses a neutral carrier membrane. The intended application of this device is the monitoring of metabolic parameters in the intensive care unit and the operation theater and the use as a sensor module in clinical analyzers. The glucose-, lactate- and pH-sensor was tested in buffer solutions and undiluted serum showing excellent performance.

Keywords: Glucose sensor, Lactate sensor, pH-sensor, Integrated biosensor, Thin-film technology

DOI: 10.3233/THC-1994-1304

Journal: Technology and Health Care, vol. 1, no. 3, pp. 215-218, 1994