Affiliations: [a] CNR Institute of Clinical Physiology, University of Pisa, 56100 Pisa, Italy | [b] Department of Angiology, Rangueil Hospital, 31054 Toulouse, Cedex, France
Correspondence:
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Mail correspondence to: Prof. Silvia Bertuglia, CNR Institute of Clinical Physiology, Via Trieste 41, 56100 Pisa, Italy. Tel.: +39 50 502771; Fax: +39 50 589038.
Abstract: Flowmotion was characterized in healthy controls and 61 Raynaud’s phenomenon (RP) patients by spectral analysis of laser-Doppler perfusion monitoring (LDPM) tracings. Healthy subjects flowmotion patterns revealed a main frequency of 3 cycles per min (cpm) with another low frequency and heart rate synchronous components. A first group of RP patients presented a low frequency and heart rate frequency component but no significant difference in blood flow. The second group presented the predominating heart rate related frequency with low microvascular perfusion. The third group presented a flowmotion pattern with overlapping of heart rate and low frequency components. Patients with primary and secondary RP show specific changes in flowmotion, probably related to increased sympathetic nervous activity or vessel wall alterations causing disappearance of arteriolar tone and impairment of microvascular perfusion. The group of patients with overlapping frequency components presents an intermediate flowmotion pattern indicating a different grade of alterations in microvasculature.
