Affiliations: [a] IPQ Analytics, LLC, Kennett Square, PA, USA | [b] Epidemiology and Health Research, National Research Council of Italy, CNR-Pisa, Italy
Correspondence:
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Corresponding author: Michael N. Liebman, IPQ Analytics, LLC, Kennett Square, PA, USA. E-mail: [email protected].
Abstract: To date, the actual rate of successful translation has been extremely low although those few successes have been notable and provide for continued and expanding enthusiasm and support. This paper examines whether the fundamental premise may be flawed. Could the success rate be improved to further enhance quality of life and cost optimization for patients by changing the paradigm to “bedside to bench to bedside”, and focusing the research on addressing unmet clinical needs? It examines all aspects of the healthcare ecosystem to understand issues that arise with real world patients and in real world clinical practice and how addressing these should be the focus of translational research.
Keywords: Translational medicine, unmet clinical needs, breast cancer, rare disease
